| Literature DB >> 27381214 |
Beatriz Samara de Brito1, Natália Giovanelli Gaspar1, Erika Said Abu Egal1, Celeste Sanchez-Romero2, Antonio Santos Martins3, Álfio José Tincani3, Rogério de Oliveira Gondak4, Oslei Paes de Almeida2, Luiz Paulo Kowalski5, Albina Altemani1, Fernanda Viviane Mariano6,7.
Abstract
The proto-oncogene (pleomorphic adenoma gene 1 (PLAG1)) is immunohistochemically overexpressed in pleomorphic adenoma (PA). Its expression in recurrent pleomorphic adenoma (RPA), however, has not been investigated. Since complex mechanisms are involved in tumor recurrence, the aim of this study was to investigate whether PLAG1 overexpression occurs in RPA. We studied PLAG1 protein expression in 40 PAs and 36 RPAs by immunohistochemistry. Cases with immunopositive cells were classified into two categories, between 10 and 50 % and >50 %. In both groups, PLAG1 expression was observed in both epithelial and myoepithelial cells. Of PAs, 37 cases (93 %) were positive, while this was the case in 34 RPA cases (94 %). Our findings suggest that in addition to morphological similarity, PA and RPA express PLAG1, which might play a role in tumor recurrence. Furthermore, as for PA, expression of PLAG1 can be considered a valuable diagnostic marker for RPA.Entities:
Keywords: Immunohistochemistry; PLAG1; Pleomorphic adenoma; Recurrent pleomorphic adenoma
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Year: 2016 PMID： 27381214 DOI： 10.1007/s00428-016-1980-3
Source DB: PubMed Journal: Virchows Arch ISSN： 0945-6317 Impact factor: 4.064