Literature DB >> 27379380

Hypervalent Iodine(III) Mediated Synthesis of 3-Substituted 5-Amino-1,2,4-thiadiazoles through Intramolecular Oxidative S-N Bond Formation.

Arumugam Mariappan1, Kandasamy Rajaguru1, Noufal Merukan Chola1, Shanmugam Muthusubramanian1, Nattamai Bhuvanesh2.   

Abstract

An efficient synthesis of 3-substituted-5-arylamino-1,2,4-thiadiazoles through intramolecular oxidative S-N bond formation of imidoyl thioureas by phenyliodine(III) bis(trifluoroacetate) is reported. The protocol features a metal-free approach, broad substrate scope, very short reaction times, good to excellent yields, and simple starting materials.

Entities:  

Year:  2016        PMID： 27379380     DOI： 10.1021/acs.joc.6b01199

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  2 in total

1.  External oxidant-free and transition metal-free synthesis of 5-amino-1,2,4-thiadiazoles as promising antibacterials against ESKAPE pathogen strains.

Authors:  Anton Shetnev; Marina Tarasenko; Valentina Kotlyarova; Sergey Baykov; Kirill Geyl; Svetlana Kasatkina; Nikolina Sibinčić; Vladimir Sharoyko; Elizaveta V Rogacheva; Liudmila A Kraeva
Journal:  Mol Divers       Date:  2022-05-31       Impact factor: 2.943

2.  Synthesis of novel series of 3,5-disubstituted imidazo[1,2-d] [1,2,4]thiadiazoles involving SNAr and Suzuki-Miyaura cross-coupling reactions.

Authors:  Clémentine Pescheteau; Matthieu Place; Alexandru Sava; Lea Nunes; Lenuta Profire; Sylvain Routier; Frédéric Buron
Journal:  RSC Adv       Date:  2022-02-23       Impact factor: 3.361
  2 in total

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