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Literature DB >> 27379361

A novel anticancer theranostic pro-prodrug based on hypoxia and photo sequential control.

Weipei Feng¹, Chunyue Gao, Wei Liu, Huihui Ren, Chao Wang, Kun Ge, Shenghui Li, Guoqiang Zhou, Hongyan Li, Shuxiang Wang, Guang Jia, Zhenhua Li, Jinchao Zhang.

Abstract

A novel anticancer pro-prodrug (GMC-CAE-NO2) with diagnosis and therapy functions based on hypoxia and photo sequential control was designed. It provides a platform for constructing theranostic pro-prodrugs to release active drugs controlled by hypoxic status and UV illumination.

Entities: Disease

Mesh：

Substances：

Year: 2016 PMID： 27379361 DOI： 10.1039/c6cc02932a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

10 in total

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Journal: Adv Mater Date: 2017-03-29 Impact factor: 30.849

2. A Molecular Logic Gate for Developing "AND" Logic Probes and the Application in Hepatopathy Differentiation.

Authors: Mengqi Chen; Chunhong Wang; Zexuan Ding; Hao Wang; Yu Wang; Zhibo Liu
Journal: ACS Cent Sci Date: 2022-06-06 Impact factor: 18.728

3. Anticancer Agent with Inexplicable Potency in Extreme Hypoxia: Characterizing a Light-Triggered Ruthenium Ubertoxin.

Authors: Houston D Cole; John A Roque; Ge Shi; Liubov M Lifshits; Elamparuthi Ramasamy; Patrick C Barrett; Rachel O Hodges; Colin G Cameron; Sherri A McFarland
Journal: J Am Chem Soc Date: 2021-12-09 Impact factor: 16.383

4. Intraligand Excited States Turn a Ruthenium Oligothiophene Complex into a Light-Triggered Ubertoxin with Anticancer Effects in Extreme Hypoxia.

Authors: John A Roque Iii; Houston D Cole; Patrick C Barrett; Liubov M Lifshits; Rachel O Hodges; Susy Kim; Gagan Deep; Antonio Francés-Monerris; Marta E Alberto; Colin G Cameron; Sherri A McFarland
Journal: J Am Chem Soc Date: 2022-04-28 Impact factor: 16.383

5. Os(II) Oligothienyl Complexes as a Hypoxia-Active Photosensitizer Class for Photodynamic Therapy.

Authors: John A Roque; Patrick C Barrett; Houston D Cole; Liubov M Lifshits; Evan Bradner; Ge Shi; David von Dohlen; Susy Kim; Nino Russo; Gagan Deep; Colin G Cameron; Marta E Alberto; Sherri A McFarland
Journal: Inorg Chem Date: 2020-10-30 Impact factor: 5.165

Review 10. Development of Photoremovable Linkers as a Novel Strategy to Improve the Pharmacokinetics of Drug Conjugates and Their Potential Application in Antibody-Drug Conjugates for Cancer Therapy.

Authors: Audrey Nathania Johan; Yi Li
Journal: Pharmaceuticals (Basel) Date: 2022-05-25

10 in total

A novel anticancer theranostic pro-prodrug based on hypoxia and photo sequential control.

Review 1. Cancer-Associated, Stimuli-Driven, Turn on Theranostics for Multimodality Imaging and Therapy.

2. A Molecular Logic Gate for Developing "AND" Logic Probes and the Application in Hepatopathy Differentiation.

3. Anticancer Agent with Inexplicable Potency in Extreme Hypoxia: Characterizing a Light-Triggered Ruthenium Ubertoxin.

4. Intraligand Excited States Turn a Ruthenium Oligothiophene Complex into a Light-Triggered Ubertoxin with Anticancer Effects in Extreme Hypoxia.

5. Os(II) Oligothienyl Complexes as a Hypoxia-Active Photosensitizer Class for Photodynamic Therapy.

Review 6. Fluorogenic reaction-based prodrug conjugates as targeted cancer theranostics.

Review 7. Strategies for using nanoprobes to perceive and treat cancer activity: a review.

8. A bifunctional molecule-based strategy for the development of theranostic antibody-drug conjugate.

9. microRNAs in cancer chemoresistance: The sword and the shield.

Review 10. Development of Photoremovable Linkers as a Novel Strategy to Improve the Pharmacokinetics of Drug Conjugates and Their Potential Application in Antibody-Drug Conjugates for Cancer Therapy.