Javier de Miguel-Díez1,2, Nuria Muñoz-Rivas3, Rodrigo Jiménez-García3, Valentín Hernández-Barrera4, Pilar Carrasco-Garrido4, Manuel Monreal5, David Jiménez6, Ricardo Guijarro7, Ana López de Andrés4. 1. Respiratory Department, Gregorio Marañón University Hospital, Madrid, Spain. javier.miguel@salud.madrid.org. 2. Faculty of Medicine, Complutense University of Madrid (UCM), Gregorio Marañón Health Research Institute (IiSGM), Madrid, Spain. javier.miguel@salud.madrid.org. 3. Department of Internal Medicine, Infanta Leonor University Hospital, Madrid, Spain. 4. Preventive Medicine and Public Health Teaching and Research Unit, Department of Health Sciences, Rey Juan Carlos University, Madrid, Spain. 5. Department of Internal Medicine, Germans Trias i Pujol University Hospital, Barcelona, Spain. 6. Respiratory Department, Ramón y Cajal Hospital, IRYCIS, Madrid, Spain. 7. Department of Internal Medicine, Carlos Haya Hospital, Málaga, Spain.
Abstract
BACKGROUND AND OBJECTIVE: We compared the incidence and outcome of pulmonary embolism (PE) in individuals with and without type 2 diabetes mellitus (T2DM) in Spain during 2004-2013. METHODS: The study was based on National Hospital Discharge Data, and the study population comprised patients hospitalized for PE. Annual incidence rates were classified according to T2DM status. In-hospital mortality (IHM), length of hospital stay (LOHS), comorbidities and use of diagnosis and therapeutic procedures were analysed. RESULTS: We identified 123 872 discharges of patients (56 361 men and 67 511 women) with PE as their primary diagnosis (15.3% with T2DM). Incidence of discharge diagnoses of PE increased significantly in all groups. Crude rates were higher in diabetic patients. A positive association was identified between T2DM and PE: adjusted IRR was 2.00 (95% CI: 1.95-2.05) for men and 2.50 (95% CI: 2.45-2.57) for women. LOHS, readmissions and IHM decreased significantly for both groups. An association between IHM and risk factors (older age, Charlson comorbidity index >3, atrial fibrillation and cancer) was observed. T2DM was associated with higher IHM in men (OR: 1.22, 95% CI: 1.12-1.32) and women (OR: 1.24, 95% CI: 1.15-1.33). The use of computed tomography pulmonary angiography increased significantly overtime. CONCLUSION: We confirmed that in both men and women, diabetes was an independent risk factor for IHM. The incidence of discharge of patients with PE increased significantly during the study period. Diabetic men and women had a higher risk of hospitalization for PE than non-diabetic men and women. Diabetic women had higher IHM than diabetic men.
BACKGROUND AND OBJECTIVE: We compared the incidence and outcome of pulmonary embolism (PE) in individuals with and without type 2 diabetes mellitus (T2DM) in Spain during 2004-2013. METHODS: The study was based on National Hospital Discharge Data, and the study population comprised patients hospitalized for PE. Annual incidence rates were classified according to T2DM status. In-hospital mortality (IHM), length of hospital stay (LOHS), comorbidities and use of diagnosis and therapeutic procedures were analysed. RESULTS: We identified 123 872 discharges of patients (56 361 men and 67 511 women) with PE as their primary diagnosis (15.3% with T2DM). Incidence of discharge diagnoses of PE increased significantly in all groups. Crude rates were higher in diabeticpatients. A positive association was identified between T2DM and PE: adjusted IRR was 2.00 (95% CI: 1.95-2.05) for men and 2.50 (95% CI: 2.45-2.57) for women. LOHS, readmissions and IHM decreased significantly for both groups. An association between IHM and risk factors (older age, Charlson comorbidity index >3, atrial fibrillation and cancer) was observed. T2DM was associated with higher IHM in men (OR: 1.22, 95% CI: 1.12-1.32) and women (OR: 1.24, 95% CI: 1.15-1.33). The use of computed tomography pulmonary angiography increased significantly overtime. CONCLUSION: We confirmed that in both men and women, diabetes was an independent risk factor for IHM. The incidence of discharge of patients with PE increased significantly during the study period. Diabeticmen and women had a higher risk of hospitalization for PE than non-diabeticmen and women. Diabeticwomen had higher IHM than diabeticmen.
Authors: Elif I Ekinci; Alvin Kong; Leonid Churilov; Natalie Nanayakkara; Wei Ling Chiu; Priya Sumithran; Frida Djukiadmodjo; Erosha Premaratne; Elizabeth Owen-Jones; Graeme Kevin Hart; Raymond Robbins; Andrew Hardidge; Douglas Johnson; Scott T Baker; Jeffrey D Zajac Journal: PLoS One Date: 2017-01-06 Impact factor: 3.240
Authors: Ana López-de-Andrés; Javier de Miguel-Díez; Isabel Jiménez-Trujillo; Valentín Hernández-Barrera; José M de Miguel-Yanes; Manuel Méndez-Bailón; Napoleón Pérez-Farinós; Miguel Á Ngel Salinero-Fort; Rodrigo Jiménez-García Journal: BMJ Open Date: 2017-01-05 Impact factor: 2.692
Authors: Rodrigo Jiménez-García; Romana Albaladejo-Vicente; Valentin Hernandez-Barrera; Rosa Villanueva-Orbaiz; David Carabantes-Alarcon; Javier de-Miguel-Diez; José Javier Zamorano-Leon; Ana Lopez-de-Andres Journal: Int J Environ Res Public Health Date: 2020-11-11 Impact factor: 3.390