Stefano Turolo1, Alberto Edefonti1, Marta Lepore1, Luciana Ghio1, Eva Cuzzoni2, Giuliana Decorti2, Andrea Pasini3, Marco Materassi4, Cristina Malaventura5, Fabrizio Pugliese6, Giovanni Montini1,7. 1. Pediatric Nephrology & Dialysis, Milano. Fondazione IRCCS Cà Grande Ospedale Maggiroe Policlinico, Italy. 2. Università degli Studi di Trieste Dipartimento di Scienze della Vita, Trieste, Friuli-Venezia Giulia, Italy. 3. Università degli Studi di Bologna Azienda Ospedaliera Sant/'Orsola-Malpighi, Bologna, Emilia-Romagna, Italy. 4. Ospedale Pediatrico Meyer Firenze, Toscana, Italy. 5. Università degli Studi di Ferrara, Medical Science Ferrara, Emilia-Romagna, Italy. 6. Agenzia sanitaria e sociale regionale Regione Emilia-Romagna, Ravenna, Emilia-Romagna, Italy. 7. Università degli Studi di Milano, Department of Clinical Sciences and Community Health, Milan, Italy.
Abstract
AIM: of the study was to analyse the impact of SXR rs3842689 polymorphism on the response to corticosteroids in pediatric idiopathic nephrotic syndrome. PATIENTS & METHODS: 66 children (56 steroid-sensitive, ten steroid-resistant) were studied for SXR gene polymorphism distribution. RESULTS: Steroid sensitive patients accounted for 96% of cases with In/In polymorphism, but only for 53% of cases with Del/Del polymorphism At odds ratio analysis, Del/Del represented a clear risk factor of steroid resistance (OR: 20.57; p = 0.009), while In/In was a favourable prognostic factor of steroid sensitivity. CONCLUSION: The analysis of SXR polymorphism is a promising tool to predict both the favourable response to corticosteroids and the risk of developing steroid resistance.
AIM: of the study was to analyse the impact of SXRrs3842689 polymorphism on the response to corticosteroids in pediatric idiopathic nephrotic syndrome. PATIENTS & METHODS: 66 children (56 steroid-sensitive, ten steroid-resistant) were studied for SXR gene polymorphism distribution. RESULTS:Steroid sensitive patients accounted for 96% of cases with In/In polymorphism, but only for 53% of cases with Del/Del polymorphism At odds ratio analysis, Del/Del represented a clear risk factor of steroid resistance (OR: 20.57; p = 0.009), while In/In was a favourable prognostic factor of steroid sensitivity. CONCLUSION: The analysis of SXR polymorphism is a promising tool to predict both the favourable response to corticosteroids and the risk of developing steroid resistance.
Authors: Andrea Pasini; Cristina Bertulli; Luca Casadio; Ciro Corrado; Alberto Edefonti; GianMarco Ghiggeri; Luciana Ghio; Mario Giordano; Claudio La Scola; Cristina Malaventura; Silvio Maringhini; Antonio P Mastrangelo; Marco Materassi; Francesca Mencarelli; Giovanni Messina; Elena Monti; William Morello; Giuseppe Puccio; Paola Romagnani; Giovanni Montini Journal: Front Pediatr Date: 2021-07-08 Impact factor: 3.418