Yunhui Chen1, Xin Meng2, Qiang Hu3, Hongsheng Cui2, Yongzhuo Ding1, Lu Kang1, Michal Juhás4, Andrew J Greenshaw4, Ameng Zhao1, Yuhua Wang1, Guangcheng Cui1, Ping Li5. 1. Department of Psychiatry, Qiqihar Medical University, Qiqihar, China. 2. Department of Radiology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, China. 3. Department of Clinical Psychology, Qiqihar Mental Health Center, Qiqihar, China. 4. Department of Psychiatry, University of Alberta, Edmonton, Canada. 5. Department of Psychiatry, Qiqihar Medical University, Qiqihar, China. lipingchxyy@163.com.
Abstract
AIM: Obsessive-compulsive disorder (OCD) is associated with deficits in response inhibition and planning, which are governed by the central executive network. The objective of this study was to investigate both intra- and inter-regional resting-state connectivity within the central executive network in OCD. METHODS: Thirty OCD patients and 30 matched healthy controls were scanned using resting-state functional magnetic resonance imaging. The independent component analysis was used on a separate sample of healthy controls to generate the central executive network mask for the subsequent OCD analyses. Regional homogeneity (ReHo) and seed-based functional connectivity analyses were used to explore the differences between intra- and inter-regional synchronized activity within the central executive network in OCD patients at rest. RESULTS: Increased ReHo and functional connectivity in the key regions of the central executive network, such as the orbitofrontal cortex, dorsolateral prefrontal cortex, and the angular gyrus, were found in OCD patients. Furthermore, changes in both the ReHo within the orbitofrontal cortex and the functional connectivity between the orbitofrontal cortex and angular gyrus were negatively correlated with OCD duration. CONCLUSION: The increased resting-state functional organization within the central executive network may be related to OCD patients' deficits in cognitive control and symptom progression.
AIM: Obsessive-compulsive disorder (OCD) is associated with deficits in response inhibition and planning, which are governed by the central executive network. The objective of this study was to investigate both intra- and inter-regional resting-state connectivity within the central executive network in OCD. METHODS: Thirty OCDpatients and 30 matched healthy controls were scanned using resting-state functional magnetic resonance imaging. The independent component analysis was used on a separate sample of healthy controls to generate the central executive network mask for the subsequent OCD analyses. Regional homogeneity (ReHo) and seed-based functional connectivity analyses were used to explore the differences between intra- and inter-regional synchronized activity within the central executive network in OCDpatients at rest. RESULTS: Increased ReHo and functional connectivity in the key regions of the central executive network, such as the orbitofrontal cortex, dorsolateral prefrontal cortex, and the angular gyrus, were found in OCDpatients. Furthermore, changes in both the ReHo within the orbitofrontal cortex and the functional connectivity between the orbitofrontal cortex and angular gyrus were negatively correlated with OCD duration. CONCLUSION: The increased resting-state functional organization within the central executive network may be related to OCDpatients' deficits in cognitive control and symptom progression.
Authors: Malvina O Pietrzykowski; Katrina M Daigle; Abigail B Waters; Lance P Swenson; David A Gansler Journal: Brain Imaging Behav Date: 2021-11-13 Impact factor: 3.978
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Authors: Hai-Di Shan; Yong-Ming Wang; Hui-Xin Hu; Shu-Yao Jiang; Min-Yi Chu; Yi Wang; Simon S Y Lui; Eric F C Cheung; Zhen Wang; Raymond C K Chan Journal: Eur Arch Psychiatry Clin Neurosci Date: 2021-01-03 Impact factor: 5.270