| Literature DB >> 27376951 |
Ke Xiong1, Wei Wei2, Yongjie Jin1, Shumin Wang1, Dongxu Zhao1, Shuang Wang2, Xiaoyong Gao2, Chenmeng Qiao2, Hua Yue2, Guanghui Ma2, Hai-Yan Xie3.
Abstract
A novel biomimetic immuno-magnetosome (IMS) is developed by coating a leukocyte membrane (decorated with anti-epithelial cell-adhesion molecule antibody) on a magnetic nanocluster. In addition to the good stability and magnetic controllability, the IMS also exhibits satisfactory binding avidity to circulating tumor cells but stealth property to leukocytes. As a result, rare tumor cells can be effectively enriched with undetectable leukocyte background.Entities:
Keywords: biomimetics; capture efficiency; circulating tumor cells; leukocyte backgrounds; magnetic particles
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Year: 2016 PMID: 27376951 DOI: 10.1002/adma.201601643
Source DB: PubMed Journal: Adv Mater ISSN: 0935-9648 Impact factor: 30.849