Literature DB >> 2737676

Multiple tandem 18-kb sequences clustered in the region of the acute promyelocytic leukemia breakpoint on chromosome 17.

G Moore1, P J Hedge, S H Rider, W Xu, S Hing, R Palmer, D Sheer, E Solomon.   

Abstract

This paper describes the cloning of an 18-kb sequence present in approximately 30 copies on chromosome 17. Most of these are clustered in the region of the breakpoint associated with acute promyelocytic leukemia (APL). These copies map both above and below the breakpoint, and pulsed field gel analysis indicates that the majority of these sequences lie within a region of approximately 2 megabases. The organization of these sequences appears to be that of large imperfect palindromes.

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Year:  1989        PMID: 2737676     DOI: 10.1016/0888-7543(89)90294-2

Source DB:  PubMed          Journal:  Genomics        ISSN: 0888-7543            Impact factor:   5.736


  3 in total

1.  Submegabase clusters of unstable tandem repeats unique to the Tla region of mouse t haplotypes.

Authors:  H Uehara; T Ebersole; D Bennett; K Artzt
Journal:  Genetics       Date:  1990-12       Impact factor: 4.562

2.  The gene for human erythrocyte protein 4.2 maps to chromosome 15q15.

Authors:  V Najfeld; S G Ballard; J Menninger; D C Ward; E E Bouhassira; R S Schwartz; R L Nagel; A C Rybicki
Journal:  Am J Hum Genet       Date:  1992-01       Impact factor: 11.025

3.  Loss of heterozygosity on chromosomes 17 and 18 in breast carcinoma: two additional regions identified.

Authors:  C S Cropp; R Lidereau; G Campbell; M H Champene; R Callahan
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

  3 in total

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