Literature DB >> 27376745

Therapeutic Potentials of Noncoding RNAs: Targeted Delivery of ncRNAs in Cancer Cells.

Yang Liu1, Jun Wang2.   

Abstract

Knowledge of multiple actions of short noncoding RNAs (ncRNAs) has truly allowed for viewing DNA, RNA, and protein in novel ways. The ncRNAs are an attractive new class of therapeutics, especially against undruggable targets for the treatment of cancer and other diseases. Despite the potential of ncRNAs in cancer therapy, many challenges remain, including rapid degradation and clearance, poor cellular uptake, off-target effects, and immunogenicity. Rational design, chemical modifications, and delivery carriers offer significant opportunities to overcome these challenges. In this chapter, the development of ncRNAs as cancer therapeutics from early stages to clinical trials and strategies for ncRNA-targeted delivery to cancer cells will be introduced.

Entities:  

Keywords:  Cancer therapeutics; Delivery system; MicroRNA (miRNA); RNA interference; Small interfering RNA (siRNA)

Mesh：

Substances：

Year:  2016        PMID： 27376745     DOI： 10.1007/978-981-10-1498-7_16

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  6 in total

Review 1.  Pancreatic Cancer, A Mis-interpreter of the Epigenetic Language.

Authors:  Eriko Iguchi; Stephanie L Safgren; David L Marks; Rachel L Olson; Martin E Fernandez-Zapico
Journal:  Yale J Biol Med       Date:  2016-12-23

Review 2.  Angiogenesis-related non-coding RNAs and gastrointestinal cancer.

Authors:  Zahra Sadat Razavi; Kasra Asgarpour; Maryam Mahjoubin-Tehran; Susan Rasouli; Haroon Khan; Mohammad Karim Shahrzad; Michael R Hamblin; Hamed Mirzaei
Journal:  Mol Ther Oncolytics       Date:  2021-05-15       Impact factor: 7.200

Review 3.  Editorial focus: entering into the non-coding RNA era.

Authors:  Rafal Bartoszewski; Aleksander F Sikorski
Journal:  Cell Mol Biol Lett       Date:  2018-09-18       Impact factor: 5.787

Review 4.  Novel Roles of Non-Coding RNAs in Opioid Signaling and Cardioprotection.

Authors:  Zesergio Melo; Cecilia Ishida; Maria de la Paz Goldaraz; Rocio Rojo; Raquel Echavarria
Journal:  Noncoding RNA       Date:  2018-09-17

Review 5.  Non-Coding RNA in Acute Ischemic Stroke: Mechanisms, Biomarkers and Therapeutic Targets.

Authors:  Sheng-Wen Wang; Zhong Liu; Zhong-Song Shi
Journal:  Cell Transplant       Date:  2018-10-26       Impact factor: 4.064

Review 6.  Editorial focus: understanding off-target effects as the key to successful RNAi therapy.

Authors:  Rafal Bartoszewski; Aleksander F Sikorski
Journal:  Cell Mol Biol Lett       Date:  2019-12-09       Impact factor: 5.787
  6 in total

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