Noncoding RNAs in Cancer Cell Plasticity.

Accumulating evidence has shown the presence of cancer stem cells in a wide spectrum of human cancers, which have the ability to self-renew and differentiate, thus leading to tumorigenesis, proliferation, cancer dissemination, drug resistance, and tumor relapse. Cancer cell plasticity allows tumor to invade and grow at primary or distant sites. Epithelial-mesenchymal transition (EMT) is the most important mechanism of cancer cell plasticity and cancer stem cells. Substantial evidence has supported a noncoding RNA network, especially miRNA, in regulating cancer cell plasticity and cancer stem cell biology. Besides, lncRNA is also found to participate in cancer development. Understanding the mechanisms of these processes might be valuable for developing accurate targeted therapies to tackle cancer progression and cancer stem cells.