| Literature DB >> 27374224 |
Sunil Singhal1, Pratik S Bhojnagarwala2, Shaun O'Brien3, Edmund K Moon3, Alfred L Garfall4, Abhishek S Rao2, Jon G Quatromoni2, Tom Li Stephen5, Leslie Litzky6, Charuhas Deshpande6, Michael D Feldman6, Wayne W Hancock7, Jose R Conejo-Garcia5, Steven M Albelda3, Evgeniy B Eruslanov8.
Abstract
Based on studies in mouse tumor models, granulocytes appear to play a tumor-promoting role. However, there are limited data about the phenotype and function of tumor-associated neutrophils (TANs) in humans. Here, we identify a subset of TANs that exhibited characteristics of both neutrophils and antigen-presenting cells (APCs) in early-stage human lung cancer. These APC-like "hybrid neutrophils," which originate from CD11b(+)CD15(hi)CD10(-)CD16(low) immature progenitors, are able to cross-present antigens, as well as trigger and augment anti-tumor T cell responses. Interferon-γ and granulocyte-macrophage colony-stimulating factor are requisite factors in the tumor that, working through the Ikaros transcription factor, synergistically exert their APC-promoting effects on the progenitors. Overall, these data demonstrate the existence of a specialized TAN subset with anti-tumor capabilities in human cancer.Entities:
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Year: 2016 PMID： 27374224 PMCID： PMC4945447 DOI： 10.1016/j.ccell.2016.06.001
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743