| Literature DB >> 27373655 |
Ryoko Toyoshima1, Nanae Mori, Toshihiro Suzuki, Witaya Lowtangkitcharoen, Khanit Suwanborirux, Naoki Saito.
Abstract
Eleven 2'-N-acyl derivatives (5a-k) were prepared from ecteinascidin 770 (Et 770: 1b) via known 18,6'-O-bisallyl-protected compound (3) in three steps. Their in vitro cytotoxicities were determined by measuring IC50 values against human cell lines HCT116 and DU145. 5-Isoxazolecarboylamide derivative (5i) and 4-methoxybenzoylamide derivative (5k) were found to be promising leads for further optimization.Entities:
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Year: 2016 PMID： 27373655 DOI： 10.1248/cpb.c16-00192
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645