| Literature DB >> 27373325 |
Holger Garn1, Sabine Bahn2, Bernhard T Baune3, Elisabeth B Binder4, Hans Bisgaard5, Talal A Chatila6, Triantafyllos Chavakis7, Carsten Culmsee8, Udo Dannlowski9, Steffen Gay10, James Gern11, Tari Haahtela12, Tilo Kircher13, Ulf Müller-Ladner14, Markus F Neurath15, Klaus T Preissner16, Christoph Reinhardt17, Graham Rook18, Shannon Russell19, Bernd Schmeck20, Thaddeus Stappenbeck21, Ulrich Steinhoff22, Jim van Os23, Scott Weiss24, Michael Zemlin25, Harald Renz26.
Abstract
Recent research indicates that chronic inflammatory diseases, including allergies and autoimmune and neuropsychiatric diseases, share common pathways of cellular and molecular dysregulation. It was the aim of the International von-Behring-Röntgen Symposium (October 16-18, 2014, in Marburg, Germany) to discuss recent developments in this field. These include a concept of biodiversity; the contribution of urbanization, lifestyle factors, and nutrition (eg, vitamin D); and new mechanisms of metabolic and immune dysregulation, such as extracellular and intracellular RNAs and cellular and mitochondrial stress. Epigenetic mechanisms contribute further to altered gene expression and therefore to the development of chronic inflammation. These novel findings provide the foundation for further development of preventive and therapeutic strategies.Entities:
Keywords: Chronic inflammation; biodiversity; environment; epigenetics; immune dysregulation; metabolism; stress
Mesh：
Year: 2016 PMID： 27373325 DOI： 10.1016/j.jaci.2016.02.046
Source DB: PubMed Journal: J Allergy Clin Immunol ISSN： 0091-6749 Impact factor: 10.793