Literature DB >> 2737238

One allele [G2m(n)] of the human IgG2 locus is more productive than the other.

N Rautonen1, H Sarvas, O Mäkelä.   

Abstract

Earlier investigators have shown that a high serum concentration of IgG2 and a high IgG2 antibody response to several polysaccharide antigens is associated with the allotype G2m(n) of the IgG2 subclass. We now show that the total IgG2 concentrations are significantly higher in G2m(n) than in G2m(-n) homozygotes (difference of means was 1.26-fold, p = 0.002). Furthermore, in G2m(n) heterozygotes, the G2m(n) allele contributed more than the G2m(-n) allele to specific IgG2 antibody responses and to the total IgG2.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2737238     DOI： 10.1002/eji.1830190506

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  4 in total

1.  IgG subclass distribution in serum and rectal mucosa of monozygotic twins with or without inflammatory bowel disease.

Authors:  L Helgeland; C Tysk; G Järnerot; K Kett; E Lindberg; D Danielsson; S N Andersen; P Brandtzaeg
Journal:  Gut       Date:  1992-10       Impact factor: 23.059

2.  Genetic segregation analyses of serum IgG2 levels.

Authors:  M L Marazita; H Lu; M E Cooper; S M Quinn; J Zhang; J A Burmeister; J V Califano; J P Pandey; H A Schenkein; J G Tew
Journal:  Am J Hum Genet       Date:  1996-05       Impact factor: 11.025

3.  Influence of the G2m(n) allotype and age on IgG subclass distribution in antibodies to dietary proteins in children with coeliac disease.

Authors:  N Rautonen; J Rautonen; E Savilahti
Journal:  Clin Exp Immunol       Date:  1990-08       Impact factor: 4.330

4.  Familial clustering of IGHC deletions and duplications: functional and molecular analysis.

Authors:  A Bottaro; R Gallina; A Brusco; U Cariota; C Boccazzi; M R Barilaro; A Plebani; A G Ugazio; A M van Leeuwen; G G DeLange
Journal:  Immunogenetics       Date:  1993       Impact factor: 2.846
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.