| Literature DB >> 27372044 |
Jianying Deng1, Qianjin Zhong2.
Abstract
Heart failure is the end stage of most cardiac diseases and also an important cardiovascular disease. Ventricular remodeling, a complicated pathophysiological process involving multiple molecular pathways, is a crucial mechanism for the occurrence and development of heart failure. A microRNA (miRNA) is a highly conservative noncoding molecule containing 18-25 nucleotides. miRNA is different from other RNAs. It mainly serves as an endogenous gene-regulating factor, and is a member of the complex regulatory network. It induces gene repression of target transcripts by affecting mRNA at the post-transcriptional level Vasudevan et al. (2007) . This study aimed at determining the mechanism of miRNA action in heart failure.Entities:
Keywords: Heart failure; Mechanism; MicroRNA
Mesh:
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Year: 2016 PMID: 27372044 DOI: 10.1016/j.ijcard.2016.06.185
Source DB: PubMed Journal: Int J Cardiol ISSN: 0167-5273 Impact factor: 4.164