Literature DB >> 27370684

HLA-A, -B, -C, -DRB1 and -DQB1 alleles and haplotypes in 951 Southeast Asia Malays from Peninsular Malaysia.

Lay-Kim Tan1, Baharin Mohd-Farid2, Sulaiman Salsabil2, Hussein Heselynn3, Sulaiman Wahinuddin4, Ing-Soo Lau5, Suk-Chyn Gun6, Sharil Nor-Suhaila3, M Eashwary3, Mohamed Said Mohd-Shahrir7, Mohd-Mokhtar Ainon8, Rosman Azmillah5, Othman Muhaini9, Murad Shahnaz2, Chun-Lai Too10.   

Abstract

A total of 951 Southeast Asia Malays from Peninsular Malaysia were genotyped for HLA-A, -B, -C -DRB1, and -DQB1 loci using polymerase chain reaction sequence-specific oligonucleotide probe hybridization methods. In this report, there were significant deviation from Hardy-Weinberg proportions for the HLA-A (p<0.0001), -B (p<0.0001), -DRB1 (p<0.0001) and -DQB1 (p<0.01) loci. Minor deviations from HWEP were detected for HLA-C (p=0.01). This genotype data was available in Allele Frequencies Network Database (AFND) Gonzalez-Galarza et al. (2015).
Copyright © 2016. Published by Elsevier Inc.

Entities:  

Keywords:  Genetic; HLA alleles; Malays; Population

Mesh:

Substances:

Year:  2016        PMID: 27370684     DOI: 10.1016/j.humimm.2016.06.022

Source DB:  PubMed          Journal:  Hum Immunol        ISSN: 0198-8859            Impact factor:   2.850


  6 in total

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  6 in total

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