Literature DB >> 27370209

Probing γ-secretase-substrate interactions at the single amino acid residue level.

Lucía Chávez-Gutiérrez1, Bart De Strooper2.   

Abstract

Mesh：

Substances：

Year:  2016        PMID： 27370209      PMCID： PMC4969572          DOI： 10.15252/embj.201694978

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


× No keyword cloud information.
  15 in total

1.  Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain.

Authors:  David M Bolduc; Daniel R Montagna; Yongli Gu; Dennis J Selkoe; Michael S Wolfe
Journal:  Proc Natl Acad Sci U S A       Date:  2015-12-22       Impact factor: 11.205

2.  Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate.

Authors:  Noriko Isoo; Chihiro Sato; Hiroyuki Miyashita; Mitsuru Shinohara; Nobumasa Takasugi; Yuichi Morohashi; Shoji Tsuji; Taisuke Tomita; Takeshi Iwatsubo
Journal:  J Biol Chem       Date:  2007-02-28       Impact factor: 5.157

Review 3.  Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond.

Authors:  Bart De Strooper; Lucía Chávez Gutiérrez
Journal:  Annu Rev Pharmacol Toxicol       Date:  2014-10-01       Impact factor: 13.820

4.  Nicastrin functions as a gamma-secretase-substrate receptor.

Authors:  Sanjiv Shah; Sheu-Fen Lee; Katsuhiko Tabuchi; Yi-Heng Hao; Cong Yu; Quincey LaPlant; Haydn Ball; Charles E Dann; Thomas Südhof; Gang Yu
Journal:  Cell       Date:  2005-08-12       Impact factor: 41.582

5.  Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity.

Authors:  Lucía Chávez-Gutiérrez; Alexandra Tolia; Elke Maes; Tong Li; Philip C Wong; Bart de Strooper
Journal:  J Biol Chem       Date:  2008-05-23       Impact factor: 5.157

6.  Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping.

Authors:  Akio Fukumori; Harald Steiner
Journal:  EMBO J       Date:  2016-05-23       Impact factor: 11.598

7.  Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site.

Authors:  Kengo Uemura; Katherine C Farner; Tadafumi Hashimoto; Navine Nasser-Ghodsi; Michael S Wolfe; Edward H Koo; Bradley T Hyman; Oksana Berezovska
Journal:  Nat Commun       Date:  2010-11-30       Impact factor: 14.919

8.  The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.

Authors:  Lucía Chávez-Gutiérrez; Leen Bammens; Iryna Benilova; Annelies Vandersteen; Manasi Benurwar; Marianne Borgers; Sam Lismont; Lujia Zhou; Simon Van Cleynenbreugel; Hermann Esselmann; Jens Wiltfang; Lutgarde Serneels; Eric Karran; Harrie Gijsen; Joost Schymkowitz; Frederic Rousseau; Kerensa Broersen; Bart De Strooper
Journal:  EMBO J       Date:  2012-04-13       Impact factor: 11.598

9.  The dynamic conformational landscape of gamma-secretase.

Authors:  Nadav Elad; Bart De Strooper; Sam Lismont; Wim Hagen; Sarah Veugelen; Muriel Arimon; Katrien Horré; Oksana Berezovska; Carsten Sachse; Lucía Chávez-Gutiérrez
Journal:  J Cell Sci       Date:  2015-02-01       Impact factor: 5.285

10.  Sampling the conformational space of the catalytic subunit of human γ-secretase.

Authors:  Xiao-chen Bai; Eeson Rajendra; Guanghui Yang; Yigong Shi; Sjors H W Scheres
Journal:  Elife       Date:  2015-12-01       Impact factor: 8.140
View more
  1 in total

1.  Efficient production of a mature and functional gamma secretase protease.

Authors:  Imran Khan; Sudarsan Krishnaswamy; Miheer Sabale; David Groth; Linda Wijaya; Michael Morici; Imre Berger; Christiane Schaffitzel; Paul E Fraser; Ralph N Martins; Giuseppe Verdile
Journal:  Sci Rep       Date:  2018-08-27       Impact factor: 4.379
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.