Literature DB >> 27367181

Metal-Free Synthesis of Fully Substituted Pyridines via Ring Construction Based on the Domino Reactions of Enaminones and Aldehydes.

Jie-Ping Wan1, Yanfeng Jing1, Changfeng Hu2, Shouri Sheng1.   

Abstract

An unprecedented domino reaction involving primary enaminones/enaminoesters and aldehydes has been developed for the synthesis of fully substituted pyridines. The construction of the products has been accomplished via the cascade generation of two C-C and one C-N bond by simply using TfOH as a promoter.

Entities:  

Year:  2016        PMID： 27367181     DOI： 10.1021/acs.joc.6b01149

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  5 in total

1.  Facile Synthesis for Benzo-1,4-Oxazepine Derivatives by Tandem Transformation of C-N Coupling/C-H Carbonylation.

Authors:  Xiaojia Zhao; Jiong Zhang; Zeqin Zheng; Runsheng Xu
Journal:  Molecules       Date:  2016-12-30       Impact factor: 4.411

2.  DABCO- and DBU-promoted one-pot reaction of N-sulfonyl ketimines with Morita-Baylis-Hillman carbonates: a sequential approach to (2-hydroxyaryl)nicotinate derivatives.

Authors:  Soumitra Guin; Raman Gupta; Debashis Majee; Sampak Samanta
Journal:  Beilstein J Org Chem       Date:  2018-11-02       Impact factor: 2.883

3.  Site-Selective Reaction of Enaminones and Enamine Esters for the Synthesis of Novel Diverse Morphan Derivatives.

Authors:  Xing-Mei Hu; Bei Zhou; Chang-Long Yang; Jun Lin; Sheng-Jiao Yan
Journal:  ACS Omega       Date:  2018-06-04

4.  Copper-catalyzed one-pot domino reactions via C-H bond activation: synthesis of 3-aroylquinolines from 2-aminobenzylalcohols and propiophenones under metal-organic framework catalysis.

Authors:  Ha V Dang; Hoang T B Le; Loan T B Tran; Hiep Q Ha; Ha V Le; Nam T S Phan
Journal:  RSC Adv       Date:  2018-09-07       Impact factor: 3.361

5.  Discovery of ( ±)-3-(1H-pyrazol-1-yl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazine derivatives with promising in vitro anticoronavirus and antitumoral activity.

Authors:  Parameshwara Chary Jilloju; Leentje Persoons; Sathish Kumar Kurapati; Dominique Schols; Steven De Jonghe; Dirk Daelemans; Rajeswar Rao Vedula
Journal:  Mol Divers       Date:  2021-06-24       Impact factor: 2.943
  5 in total

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