| Literature DB >> 27366955 |
Jingyi Zhang1, Qingshuang Zhang1, Biao Xia1, Jie Wu1, Xiao-Na Wang1, Junbiao Chang1.
Abstract
We present a metal-free [2 + 2 + 2] cycloaddition of ynamides with nitriles that enables highly efficient access to 2,4-diaminopyridines. This catalytic protocol is more environmentally friendly and allows for a concomitant construction of C-C and C-N bonds between ynamides and nitriles, exhibiting excellent chemoselectivity, regioselectivity, and wide functional groups tolerance.Entities:
Year: 2016 PMID： 27366955 DOI： 10.1021/acs.orglett.6b01546
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005