Literature DB >> 27366543

A Case Report of the First Propofol Addiction in Turkey.

Gültürk Köroğlu1, Aysu Hayriye Tezcan2.   

Abstract

Propofol is a potent anaesthetic drug and also an effective sedative agent. Also, propofol may be used for non-anaesthetic purposes such as the treatment of seizures, migraine and tension headache in clinical practice. It has been abused, particularly among healthcare providers with high mortality rate. This report presents the case of a propofol-dependent patient who was an emergency medicine doctor with no difficulties in obtaining the drug. He himself visited our clinic for the treatment of propofol dependence. We started the patient's treatment with pharmacotherapeutic medicines and individual psychotherapy. Fourteen days after starting the therapy, the patient was discharged from hospital on his own will and he did not attend the follow-up visits in the outpatient clinic. Then, we were informed of his death, which was suspected to have occurred owing to drug intoxication in the hospital in which he worked. Nevertheless, the reason of death was important; the importance of this case report is to provide information regarding the drug's dependence profile. This is the first case report indicating propofol dependence in Turkey. Because of its easy access, rapid onset time and short duration of action, propofol dependence is increasing. We think that adding propofol to the controlled drug list and improving the knowledge of the clinicians regarding its abuse potential may limit the dependence cases.

Entities:  

Keywords:  Propofol; abuse; dependence; euphoria

Year:  2015        PMID: 27366543      PMCID: PMC4894190          DOI: 10.5152/TJAR.2015.54872

Source DB:  PubMed          Journal:  Turk J Anaesthesiol Reanim        ISSN: 2149-276X


  13 in total

1.  Propofol dependency in a lay person.

Authors:  Georg A Fritz; Wolfgang E Niemczyk
Journal:  Anesthesiology       Date:  2002-02       Impact factor: 7.892

2.  Anesthesiologist addicted to propofol.

Authors:  J W Follette; W J Farley
Journal:  Anesthesiology       Date:  1992-10       Impact factor: 7.892

3.  A case of propofol dependence after repeated use for endoscopy.

Authors:  S Roh; J M Park; D J Kim
Journal:  Endoscopy       Date:  2011-11-08       Impact factor: 10.093

4.  Death related to a recreational abuse of propofol at therapeutic dose range.

Authors:  A Roussin; M Mirepoix; G Lassabe; V Dumestre-Toulet; V Gardette; J-L Montastruc; M Lapeyre-Mestre
Journal:  Br J Anaesth       Date:  2006-08       Impact factor: 9.166

5.  Propofol dependency after treatment of tension headache.

Authors:  Udo Schneider; Dominique Rada; Jens D. Rollnik; Thorsten Passie; Hinderk M. Emrich
Journal:  Addict Biol       Date:  2001-07       Impact factor: 4.280

Review 6.  Propofol: therapeutic indications and side-effects.

Authors:  Paul E Marik
Journal:  Curr Pharm Des       Date:  2004       Impact factor: 3.116

7.  A prospective safety study of a low-dose propofol sedation protocol for colonoscopy.

Authors:  Brian W Sipe; Mark Scheidler; Arthur Baluyut; Betty Wright
Journal:  Clin Gastroenterol Hepatol       Date:  2007-05       Impact factor: 11.382

8.  A fatality due to propofol poisoning.

Authors:  O H Drummer
Journal:  J Forensic Sci       Date:  1992-07       Impact factor: 1.832

Review 9.  Pharmacological and clinical evidences on the potential for abuse and dependence of propofol: a review of the literature.

Authors:  Anne Roussin; Jean-Louis Montastruc; Maryse Lapeyre-Mestre
Journal:  Fundam Clin Pharmacol       Date:  2007-10       Impact factor: 2.748

10.  Abuse potential assessment of propofol by its subjective effects after sedation.

Authors:  Aysu Hayriye Tezcan; Dilsen Hatice Ornek; Onur Ozlu; Mustafa Baydar; Nurcan Yavuz; Nihal Gokbulut Ozaslan; Kevser Dilek; Aylin Keske
Journal:  Pak J Med Sci       Date:  2014 Nov-Dec       Impact factor: 1.088

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  1 in total

1.  Bispectral Index Monitoring and Observer Rating Scale Correlate with Dreaming during Propofol Anesthesia for Gastrointestinal Endoscopies.

Authors:  Helena Matus; Slavica Kvolik; Andreja Rakipovic; Vladimir Borzan
Journal:  Medicina (Kaunas)       Date:  2021-12-31       Impact factor: 2.430

  1 in total

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