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Literature DB >> 27365883

Lactate levels with glioblastoma multiforme.

Arunpreet Singh Kahlon¹, Mariam Alexander¹, Arundeep Kahlon¹, Jonathan Wright¹.

Abstract

A 37-year-old woman with known glioblastoma multiforme was admitted for treatment of new deep vein thrombosis. Anion gap and plasma lactate levels were found to be elevated. Magnetic resonance imaging of the brain showed a stable, advanced glioblastoma multiforme. All causes of lactic acidosis, including infections and medications, were ruled out. Aggressive tumors have been shown to produce lactate levels in minute quantities in their microenvironment, which helps them metastasize and evade immune response and even radiation.

Entities: Chemical Disease Species

Year: 2016 PMID： 27365883 PMCID： PMC4900781 DOI： 10.1080/08998280.2016.11929449

Source DB: PubMed Journal: Proc (Bayl Univ Med Cent) ISSN： 0899-8280

17 in total

1. Warburg's effect on solid tumors.

Authors: Talal El Imad; Lara El Khoury; Abdallah Sassine Geara
Journal: Saudi J Kidney Dis Transpl Date: 2014-11

2. Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors.

Authors: Qi-Wen Fan; William A Weiss
Journal: Methods Mol Biol Date: 2012

3. Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release.

Authors: Kristina Goetze; Stefan Walenta; Magdalena Ksiazkiewicz; Leoni A Kunz-Schughart; Wolfgang Mueller-Klieser
Journal: Int J Oncol Date: 2011-05-25 Impact factor: 5.650

Review 4. Etiology and therapeutic approach to elevated lactate levels.

Authors: Lars W Andersen; Julie Mackenhauer; Jonathan C Roberts; Katherine M Berg; Michael N Cocchi; Michael W Donnino
Journal: Mayo Clin Proc Date: 2013-10 Impact factor: 7.616

Review 5. Suppression of T-cell responses by tumor metabolites.

Authors: Katrin Singer; Eva Gottfried; Marina Kreutz; Andreas Mackensen
Journal: Cancer Immunol Immunother Date: 2011-01-15 Impact factor: 6.968

6. Evaluation of MR markers that predict survival in patients with newly diagnosed GBM prior to adjuvant therapy.

Authors: Suja Saraswathy; Forrest W Crawford; Kathleen R Lamborn; Andrea Pirzkall; Susan Chang; Soonmee Cha; Sarah J Nelson
Journal: J Neurooncol Date: 2008-09-23 Impact factor: 4.130

Review 7. Lactate production under fully aerobic conditions: the lactate shuttle during rest and exercise.

Authors: G A Brooks
Journal: Fed Proc Date: 1986-12

8. Glycolytic metabolism and tumour response to fractionated irradiation.

Authors: Ulrike G A Sattler; Sandra S Meyer; Verena Quennet; Christian Hoerner; Hannah Knoerzer; Christian Fabian; Ala Yaromina; Daniel Zips; Stefan Walenta; Michael Baumann; Wolfgang Mueller-Klieser
Journal: Radiother Oncol Date: 2009-12-28 Impact factor: 6.280

9. Suppression of lactate dehydrogenase A compromises tumor progression by downregulation of the Warburg effect in glioblastoma.

Authors: Juan Li; Shuchai Zhu; Jing Tong; Hui Hao; Jie Yang; Zhikun Liu; Yuxiang Wang
Journal: Neuroreport Date: 2016-01-20 Impact factor: 1.837

Lactate levels with glioblastoma multiforme.

1. Warburg's effect on solid tumors.

2. Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors.

3. Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release.

Review 4. Etiology and therapeutic approach to elevated lactate levels.

Review 5. Suppression of T-cell responses by tumor metabolites.

6. Evaluation of MR markers that predict survival in patients with newly diagnosed GBM prior to adjuvant therapy.

Review 7. Lactate production under fully aerobic conditions: the lactate shuttle during rest and exercise.

8. Glycolytic metabolism and tumour response to fractionated irradiation.

9. Suppression of lactate dehydrogenase A compromises tumor progression by downregulation of the Warburg effect in glioblastoma.

Review 10. The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor.

Review 1. Elucidating immunometabolic targets in glioblastoma.

Review 2. Drug Resistance in Glioblastoma: The Two Faces of Oxidative Stress.

3. Type B lactic acidosis: a rare oncological emergency.

Review 4. Glioblastoma Chemoresistance: The Double Play by Microenvironment and Blood-Brain Barrier.