Literature DB >> 27365452

Immune modulation by MANF promotes tissue repair and regenerative success in the retina.

Joana Neves1, Jie Zhu1, Pedro Sousa-Victor1, Mia Konjikusic1, Rebeccah Riley1, Shereen Chew1, Yanyan Qi1, Heinrich Jasper2, Deepak A Lamba2.   

Abstract

Regenerative therapies are limited by unfavorable environments in aging and diseased tissues. A promising strategy to improve success is to balance inflammatory and anti-inflammatory signals and enhance endogenous tissue repair mechanisms. Here, we identified a conserved immune modulatory mechanism that governs the interaction between damaged retinal cells and immune cells to promote tissue repair. In damaged retina of flies and mice, platelet-derived growth factor (PDGF)-like signaling induced mesencephalic astrocyte-derived neurotrophic factor (MANF) in innate immune cells. MANF promoted alternative activation of innate immune cells, enhanced neuroprotection and tissue repair, and improved the success of photoreceptor replacement therapies. Thus, immune modulation is required during tissue repair and regeneration. This approach may improve the efficacy of stem-cell-based regenerative therapies.
Copyright © 2016, American Association for the Advancement of Science.

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Year:  2016        PMID： 27365452      PMCID： PMC5270511          DOI： 10.1126/science.aaf3646

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  82 in total

1.  Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration.

Authors:  Nisha Gupta; Kimberly E Brown; Ann H Milam
Journal:  Exp Eye Res       Date:  2003-04       Impact factor: 3.467

Review 2.  Drosophila as a model of wound healing and tissue regeneration in vertebrates.

Authors:  Yaiza Belacortu; Nuria Paricio
Journal:  Dev Dyn       Date:  2011-09-26       Impact factor: 3.780

3.  The Rpe65 Leu450Met variation increases retinal resistance against light-induced degeneration by slowing rhodopsin regeneration.

Authors:  A Wenzel; C E Reme; T P Williams; F Hafezi; C Grimm
Journal:  J Neurosci       Date:  2001-01-01       Impact factor: 6.167

Review 4.  Microglia in the healthy and degenerating retina: insights from novel mouse models.

Authors:  Marcus Karlstetter; Stefanie Ebert; Thomas Langmann
Journal:  Immunobiology       Date:  2010-06-04       Impact factor: 3.144

5.  Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage.

Authors:  Jason Karpac; Andrew Younger; Heinrich Jasper
Journal:  Dev Cell       Date:  2011-06-14       Impact factor: 12.270

6.  Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors.

Authors:  Masayuki Akimoto; Hong Cheng; Dongxiao Zhu; Joseph A Brzezinski; Ritu Khanna; Elena Filippova; Edwin C T Oh; Yuezhou Jing; Jose-Luis Linares; Matthew Brooks; Sepideh Zareparsi; Alan J Mears; Alfred Hero; Tom Glaser; Anand Swaroop
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-27       Impact factor: 11.205

7.  Adult donor rod photoreceptors integrate into the mature mouse retina.

Authors:  Juliane Gust; Thomas A Reh
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-07-15       Impact factor: 4.799

8.  Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.

Authors:  Christopher N Parkhurst; Guang Yang; Ipe Ninan; Jeffrey N Savas; John R Yates; Juan J Lafaille; Barbara L Hempstead; Dan R Littman; Wen-Biao Gan
Journal:  Cell       Date:  2013-12-19       Impact factor: 41.582

9.  Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo.

Authors:  Päivi Lindholm; Merja H Voutilainen; Juha Laurén; Johan Peränen; Veli-Matti Leppänen; Jaan-Olle Andressoo; Maria Lindahl; Sanna Janhunen; Nisse Kalkkinen; Tõnis Timmusk; Raimo K Tuominen; Mart Saarma
Journal:  Nature       Date:  2007-07-05       Impact factor: 49.962

10.  CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.

Authors:  Christophe Combadière; Charles Feumi; William Raoul; Nicole Keller; Mathieu Rodéro; Adeline Pézard; Sophie Lavalette; Marianne Houssier; Laurent Jonet; Emilie Picard; Patrice Debré; Mirna Sirinyan; Philippe Deterre; Tania Ferroukhi; Salomon-Yves Cohen; Dominique Chauvaud; Jean-Claude Jeanny; Sylvain Chemtob; Francine Behar-Cohen; Florian Sennlaub
Journal:  J Clin Invest       Date:  2007-10       Impact factor: 14.808
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  85 in total

1.  Discovery of endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome.

Authors:  Sun-Ji Park; Yeawon Kim; Shyh-Ming Yang; Mark J Henderson; Wei Yang; Maria Lindahl; Fumihiko Urano; Ying Maggie Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2019-06-24       Impact factor: 11.205

Review 2.  Mesencephalic astrocyte-derived neurotrophic factor (MANF), a new player in endoplasmic reticulum diseases: structure, biology, and therapeutic roles.

Authors:  Yeawon Kim; Sun-Ji Park; Ying Maggie Chen
Journal:  Transl Res       Date:  2017-06-29       Impact factor: 7.012

Review 3.  Rejuvenating Strategies for Stem Cell-Based Therapies in Aging.

Authors:  Joana Neves; Pedro Sousa-Victor; Heinrich Jasper
Journal:  Cell Stem Cell       Date:  2017-02-02       Impact factor: 24.633

4.  Immunomodulation-accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina.

Authors:  David T White; Sumitra Sengupta; Meera T Saxena; Qingguo Xu; Justin Hanes; Ding Ding; Hongkai Ji; Jeff S Mumm
Journal:  Proc Natl Acad Sci U S A       Date:  2017-04-17       Impact factor: 11.205

Review 5.  Reconnecting Eye to Brain.

Authors:  Michael C Crair; Carol A Mason
Journal:  J Neurosci       Date:  2016-10-19       Impact factor: 6.167

6.  Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models.

Authors:  Fumiyuki Sasaki; Tomoaki Koga; Mai Ohba; Kazuko Saeki; Toshiaki Okuno; Keijiro Ishikawa; Takahito Nakama; Shintaro Nakao; Shigeo Yoshida; Tatsuro Ishibashi; Hamid Ahmadieh; Mozhgan Rezaei Kanavi; Ali Hafezi-Moghadam; Josef M Penninger; Koh-Hei Sonoda; Takehiko Yokomizo
Journal:  JCI Insight       Date:  2018-09-20

7.  A High-Resolution Genome-Wide CRISPR/Cas9 Viability Screen Reveals Structural Features and Contextual Diversity of the Human Cell-Essential Proteome.

Authors:  Thierry Bertomeu; Jasmin Coulombe-Huntington; Andrew Chatr-Aryamontri; Karine G Bourdages; Etienne Coyaud; Brian Raught; Yu Xia; Mike Tyers
Journal:  Mol Cell Biol       Date:  2017-12-13       Impact factor: 4.272

8.  MANF delivery improves retinal homeostasis and cell replacement therapies in ageing mice.

Authors:  Joana Neves; Kathleen R Chirco; Wendy Cedron-Craft; Shereen Chew; Jie Zhu; Heinrich Jasper; Deepak A Lamba
Journal:  Exp Gerontol       Date:  2020-02-28       Impact factor: 4.032

9.  Mono-macrophage-Derived MANF Protects Against Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting Inflammation and Renal M1 Macrophages.

Authors:  Chao Hou; Qiong Mei; Xuegang Song; Qin Bao; Xiang Li; Dong Wang; Yuxian Shen
Journal:  Inflammation       Date:  2020-11-03       Impact factor: 4.092

Review 10.  Pluripotent Stem Cell-Based Organoid Technologies for Developing Next-Generation Vision Restoration Therapies of Blindness.

Authors:  Ratnesh K Singh; Francois Binette; Magdalene Seiler; Simon M Petersen-Jones; Igor O Nasonkin
Journal:  J Ocul Pharmacol Ther       Date:  2020-10-14       Impact factor: 2.671
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