F M M Santos1, R W Telles2, C C D Lanna3, A L Teixeira2,4, A S Miranda4, N P Rocha4, A L Ribeiro2. 1. Department of Rheumatology, School of Medicine, Universidade Federal de Minas Gerais, Brazil famedi@ig.com.br. 2. Department of Internal Medicine, School of Medicine, Universidade Federal de Minas Gerais, Brazil. 3. Department of Rheumatology, School of Medicine, Universidade Federal de Minas Gerais, Brazil. 4. Interdisciplinary Laboratory for Medical Research, Universidade Federal de Minas Gerais, Brazil.
Abstract
OBJECTIVES: To analyze the association of adipokines and tumor necrosis factor α (TNFα) and its receptors with characteristics of systemic lupus erythematosus (SLE) and to investigate the correlation between adipokines and the TNF system. METHODS: One hundred and thirty-six SLE women, aged ≥18 years old, were assessed. TNFα, soluble TNFα receptors 1 (sTNFR1) and 2 (sTNFR2) and adipokines were analyzed by ELISA kits. RESULTS: The median (IQR) of age was 41.5 (33.0-49.7) years old and of disease duration 11.3 (7.8-15.8) years. The median (IQR) of disease activity was 0 (0-4) and of damage index was 2 (1-3). Higher levels of sTNFR1 and sTNFR2 were associated with nephritis (p < 0.001 for both), and sTNFR1 (p = 0.025) and TNFα (p = 0.014) were positively associated with arthritis. Higher sTNFR1 levels were found in participants that were not using antimalarial drugs (p = 0.04). Independent correlation was found between sTNFR1 (β = 0.253; p = 0.003) and sTNFR2 (β = 0.297; p < 0.001) levels and disease activity and damage index (sTNFR1: β = 0.367; p < 0.001; sTNFR2: β = 0.335; p < 0.001). Higher adiponectin levels were independently associated with nephritis (p = 0.009) and antimalarial drugs use (p = 0.015). There was a positive correlation between leptin and sTNFR2 levels (p = 0.002) and between resistin levels and sTNFR1 (p < 0.001) and sTNFR2 (p < 0.001). CONCLUSION: The correlation between adipokines and TNF system allows a better understanding of the role of adipokines in the inflammatory response in SLE patients.
OBJECTIVES: To analyze the association of adipokines and tumor necrosis factor α (TNFα) and its receptors with characteristics of systemic lupus erythematosus (SLE) and to investigate the correlation between adipokines and the TNF system. METHODS: One hundred and thirty-six SLEwomen, aged ≥18 years old, were assessed. TNFα, soluble TNFα receptors 1 (sTNFR1) and 2 (sTNFR2) and adipokines were analyzed by ELISA kits. RESULTS: The median (IQR) of age was 41.5 (33.0-49.7) years old and of disease duration 11.3 (7.8-15.8) years. The median (IQR) of disease activity was 0 (0-4) and of damage index was 2 (1-3). Higher levels of sTNFR1 and sTNFR2 were associated with nephritis (p < 0.001 for both), and sTNFR1 (p = 0.025) and TNFα (p = 0.014) were positively associated with arthritis. Higher sTNFR1 levels were found in participants that were not using antimalarial drugs (p = 0.04). Independent correlation was found between sTNFR1 (β = 0.253; p = 0.003) and sTNFR2 (β = 0.297; p < 0.001) levels and disease activity and damage index (sTNFR1: β = 0.367; p < 0.001; sTNFR2: β = 0.335; p < 0.001). Higher adiponectin levels were independently associated with nephritis (p = 0.009) and antimalarial drugs use (p = 0.015). There was a positive correlation between leptin and sTNFR2 levels (p = 0.002) and between resistin levels and sTNFR1 (p < 0.001) and sTNFR2 (p < 0.001). CONCLUSION: The correlation between adipokines and TNF system allows a better understanding of the role of adipokines in the inflammatory response in SLEpatients.
Authors: Mary A Mahieu; Grace E Ahn; Joan S Chmiel; Dorothy D Dunlop; Irene B Helenowski; Pamela Semanik; Jing Song; Susan Yount; Rowland W Chang; Rosalind Ramsey-Goldman Journal: Rheumatol Int Date: 2018-01-04 Impact factor: 2.631
Authors: Liliane Silvano Araújo; Marcos Vinícius da Silva; Crislaine Aparecida da Silva; Maria de Fátima Borges; Heloísa Marcelina da Cunha Palhares; Laura Penna Rocha; Rosana Rosa Miranda Corrêa; Virmondes Rodrigues Júnior; Marlene Antônia Dos Reis; Juliana Reis Machado Journal: PLoS One Date: 2020-03-04 Impact factor: 3.240
Authors: Jorge Ivan Gamez-Nava; Valeria Diaz-Rizo; Edsaul Emilio Perez-Guerrero; Jose Francisco Muñoz-Valle; Ana Miriam Saldaña-Cruz; Nicte Selene Fajardo-Robledo; Heriberto Jacobo-Cuevas; Cesar Arturo Nava-Valdivia; Miriam Fabiola Alcaraz-Lopez; Xochitl Trujillo; Miguel Huerta; Ernesto German Cardona-Muñoz; Laura Gonzalez-Lopez Journal: Biomark Res Date: 2020-10-28