Literature DB >> 2736504

Urinary and faecal excretion of pyrene and hydroxypyrene by rats after oral, intraperitoneal, intratracheal or intrapulmonary application.

J Jacob1, H Brune, G Gettbarn, D Grimmer, U Heinrich, E Mohtashamipur, K Norpoth, F Pott, R Wenzel-Hartung.   

Abstract

The urinary and faecal excretion of pyrene and 1-hydroxypyrene after oral (53.4%), intraperitoneal (3.1%), intratracheal (30-37%) and intrapulmonary application (0.003%) to rats has been determined by means of gas chromatography/mass spectrometry and the excretion rates were found to depend on the mode of application. With regard to the low urinary excretion rates, 1-hydroxypyrene seems not to be very suitable as a biological marker for PAH exposure to man.

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Year:  1989        PMID： 2736504     DOI： 10.1016/0304-3835(89)90209-7

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  9 in total

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Authors:  Yan Zhong; Jing Wang; Steven G Carmella; J Bradley Hochalter; Diane Rauch; Andrew Oliver; Joni Jensen; Dorothy K Hatsukami; Pramod Upadhyaya; Cheryl Zimmerman; Stephen S Hecht
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2.  Is urinary 1-hydroxypyrene a valid biomarker for exposure to air pollution in outdoor workers? A meta-analysis.

Authors:  Manuela Ciarrocca; Maria Valeria Rosati; Francesco Tomei; Assuntina Capozzella; Giorgia Andreozzi; Gianfranco Tomei; Alessandro Bacaloni; Teodorico Casale; Jean Claude Andrè; Mario Fioravanti; Maria Fernanda Cuartas; Tiziana Caciari
Journal:  J Expo Sci Environ Epidemiol       Date:  2013-01-09       Impact factor: 5.563

3.  Urinary 1-naphthol and 1-pyrenol as indicators of exposure to coal tar products.

Authors:  P Heikkilä; M Luotamo; L Pyy; V Riihimäki
Journal:  Int Arch Occup Environ Health       Date:  1995       Impact factor: 3.015

4.  Exposure to polycyclic aromatic hydrocarbons in petrochemical industries by measurement of urinary 1-hydroxypyrene.

Authors:  P J Boogaard; N J van Sittert
Journal:  Occup Environ Med       Date:  1994-04       Impact factor: 4.402

5.  An examination of the time course from human dietary exposure to polycyclic aromatic hydrocarbons to urinary elimination of 1-hydroxypyrene.

Authors:  T J Buckley; P J Lioy
Journal:  Br J Ind Med       Date:  1992-02

6.  Biomonitoring of polycyclic aromatic hydrocarbons in highly exposed coke plant workers by measurement of urinary phenanthrene and pyrene metabolites (phenols and dihydrodiols).

Authors:  G Grimmer; G Dettbarn; J Jacob
Journal:  Int Arch Occup Environ Health       Date:  1993       Impact factor: 3.015

7.  Significance of dermal and respiratory uptake in creosote workers: exposure to polycyclic aromatic hydrocarbons and urinary excretion of 1-hydroxypyrene.

Authors:  E Elovaara; P Heikkilä; L Pyy; P Mutanen; V Riihimäki
Journal:  Occup Environ Med       Date:  1995-03       Impact factor: 4.402

8.  Characterization and tissue distribution of conjugated metabolites of pyrene in the rat.

Authors:  Aksorn Saengtienchai; Yoshinori Ikenaka; Wageh Sobhy Darwish; Shouta M M Nakayama; Hazuki Mizukawa; Mayumi Ishizuka
Journal:  J Vet Med Sci       Date:  2015-06-01       Impact factor: 1.267

9.  Vehicle-dependent disposition kinetics of fluoranthene in Fisher-344 rats.

Authors:  Deacqunita L Harris; Darry B Hood; Aramandla Ramesh
Journal:  Int J Environ Res Public Health       Date:  2008-03       Impact factor: 3.390
  9 in total

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