| Literature DB >> 27364617 |
Yoshiji Ohta1, Hisako Kubo2, Koji Yashiro3, Koji Ohashi4, Yuji Tsuzuki2, Naoya Wada2, Yasuko Yamamoto2,5, Kuniaki Saito2,5.
Abstract
The aim of this study was to clarify the effect of water-immersion restraint stress (WIRS) on tryptophan (Trp) catabolism through the kynurenine (Kyn) pathway in rat tissues. The tissues of rats subjected to 6 h of WIRS (+WIRS) had increased tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) activities and increased TDO and IDO1 (one of two IDO isozymes in mammals) mRNA expression levels, with decreased Trp and increased Kyn contents in the liver. +WIRS rats had unchanged TDO and IDO activities in the kidney, decreased TDO activity and unchanged IDO activity in the brain, and unchanged IDO activity in the lung and spleen, with increased Kyn content in all of these tissues. Pretreatment of stressed rats with RU486, a glucocorticoid antagonist, attenuated the increased TOD activity, but not the increased IDO activity, with partial recoveries of the decreased Trp and increased Kyn contents in the liver. These results indicate that WIRS enhances hepatic Trp catabolism by inducing both IDO1 and TDO in rats.Entities:
Keywords: Glucocorticoid; Indoleamine 2,3-Dioxygenase 1; Interferon-γ; Liver tryptophan catabolism; Tryptophan 2,3-Dioxygenase; Water-immersion restraint stress (rats)
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Year: 2016 PMID： 27364617 DOI： 10.1007/s12576-016-0467-y
Source DB: PubMed Journal: J Physiol Sci ISSN： 1880-6546 Impact factor: 2.781