PURPOSE: Biomarkers may predict neurological prognosis in infants with hypoxic-ischemic encephalopathy (HIE). We evaluated the relationship between serum lactate dehydrogenase (LDH) and brain magnetic resonance imaging (MRI), which predicts neurodevelopmental outcomes, in order to assess whether LDH levels are similarly predictive. MATERIALS AND METHODS: Medical records were reviewed for infants with HIE and LDH levels were assessed on the first (LDH1) and third (LDH3) days following birth. Receiver operating characteristic curves were obtained in relation to central gray matter hypoxic-ischemic lesions. RESULTS: Of 92 patients, 52 (56.5%) had hypoxic-ischemic lesions on brain MRI, and 21 of these infants (40.4%) had central gray matter lesions. LDH1 and LDH3 did not differ; however, the percentage change (ΔLDH%) was significantly higher in infants with central gray matter lesions (36.9% versus 6.6%, p = 0.006). With cutoffs of 187 (IU/L, ΔLDH) and 19.4 (%, ΔLDH%), the sensitivity, specificity, positive predictive value and negative predictive value were 71.4, 69.0, 40.5 and 89.1%, respectively. The relative risk was 5.57 (p = 0.001). CONCLUSION: Changes in serum LDH may be a useful biomarker for predicting future neurodevelopmental prognosis in infants with HIE.
PURPOSE: Biomarkers may predict neurological prognosis in infants with hypoxic-ischemicencephalopathy (HIE). We evaluated the relationship between serum lactate dehydrogenase (LDH) and brain magnetic resonance imaging (MRI), which predicts neurodevelopmental outcomes, in order to assess whether LDH levels are similarly predictive. MATERIALS AND METHODS: Medical records were reviewed for infants with HIE and LDH levels were assessed on the first (LDH1) and third (LDH3) days following birth. Receiver operating characteristic curves were obtained in relation to central gray matter hypoxic-ischemic lesions. RESULTS: Of 92 patients, 52 (56.5%) had hypoxic-ischemic lesions on brain MRI, and 21 of these infants (40.4%) had central gray matter lesions. LDH1 and LDH3 did not differ; however, the percentage change (ΔLDH%) was significantly higher in infants with central gray matter lesions (36.9% versus 6.6%, p = 0.006). With cutoffs of 187 (IU/L, ΔLDH) and 19.4 (%, ΔLDH%), the sensitivity, specificity, positive predictive value and negative predictive value were 71.4, 69.0, 40.5 and 89.1%, respectively. The relative risk was 5.57 (p = 0.001). CONCLUSION: Changes in serum LDH may be a useful biomarker for predicting future neurodevelopmental prognosis in infants with HIE.
Entities:
Keywords:
Central gray matter; hypoxic ischemic encephalopathy; lactate dehydrogenase; magnetic resonance imaging; neurodevelopment
Authors: Wei Chen; Lan-Fen Chen; Meng-Bei Zhang; Yu-Peng Xia; Yue-Hua Zhao; Guang-Zu Li; Xiao-Li Wang Journal: Zhongguo Dang Dai Er Ke Za Zhi Date: 2019-08
Authors: Niels Hansen; Daniel Luedecke; Berend Malchow; Michael Lipp; Jonathan Vogelgsang; Charles Timäus; Tristan Zindler; Stefan Gingele; Simone Kühn; Jürgen Gallinat; Klaus Wiedemann; Johannes Denk; Nicole Moschny; Jens Fiehler; Thomas Skripuletz; Christian Riedel; Mike P Wattjes; Inga Zerr; Hermann Esselmann; Luise Poustka; Anne Karow; Hans Hartmann; Helge Frieling; Stefan Bleich; Jens Wiltfang; Alexandra Neyazi Journal: J Neural Transm (Vienna) Date: 2021-05-31 Impact factor: 3.575
Authors: Cecilia Pegelow Halvorsen; Linus Olson; Ana Catarina Araújo; Mathias Karlsson; Trang Thị Nguyễn; Dung T K Khu; Ha T T Le; Hoa T B Nguyễn; Birger Winbladh; Aman Russom Journal: Sci Rep Date: 2019-06-26 Impact factor: 4.379
Authors: L Grego; S Pignatto; E Busolini; N Rassu; F Samassa; R Prosperi; C Pittini; L Cattarossi; Paolo Lanzetta Journal: Graefes Arch Clin Exp Ophthalmol Date: 2020-11-03 Impact factor: 3.117
Authors: José David Piñeiro-Ramos; Antonio Núñez-Ramiro; Roberto Llorens-Salvador; Anna Parra-Llorca; Ángel Sánchez-Illana; Guillermo Quintás; Nuria Boronat-González; Juan Martínez-Rodilla; Julia Kuligowski; Máximo Vento Journal: Metabolites Date: 2020-03-14