Literature DB >> 2735932

Enhancement of methotrexate-induced growth inhibition, cell killing and DNA lesions in cultured L5178Y cells by the reduction of DNA repair efficiency.

B Gołos1, J Malec.   

Abstract

Acute treatment of L5178Y cells by methotrexate (MTX) caused concentration-dependent post-treatment growth inhibition and cell killing. The effects were potentiated in the presence of caffeine (CAF). At the same experimental conditions the CAF-dependent increase in mature and newly formed DNA lesions was found. The results suggest that even short MTX treatment can cause DNA lesions which are normally, at least partially, repaired. By the reduction of DNA repair efficiency with CAF, these lesions can be expressed what finds its reflection in the enhancement of MTX cytotoxicity.

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Year:  1989        PMID： 2735932     DOI： 10.1016/0006-2952(89)90407-3

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  3 in total

1.  Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease.

Authors:  Inna I Kruman; T S Kumaravel; Althaf Lohani; Ward A Pedersen; Roy G Cutler; Yuri Kruman; Norman Haughey; Jaewon Lee; Michele Evans; Mark P Mattson
Journal:  J Neurosci       Date:  2002-03-01       Impact factor: 6.167

2.  Antimetabolite-induced increases in the invasive capacity of murine leukaemia L1210 cells.

Authors:  T W De Graaf; G J Peters; W van Dijk
Journal:  Clin Exp Metastasis       Date:  1994-03       Impact factor: 5.150

3.  Antifolates can potentiate topoisomerase II inhibitors in vitro and in vivo.

Authors:  S A Holden; B A Teicher; M F Robinson; D Northey; A Rosowsky
Journal:  Cancer Chemother Pharmacol       Date:  1995       Impact factor: 3.333
  3 in total

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