A Lecoindre1, P Lecoindre2, J L Cadoré3, M Chevallier4, S Guerret4, G Derré5, S P Mcdonough6, K W Simpson7. 1. Service de Médecine Interne, VetAgro Sup Campus Vétérinaire, Université de Lyon, 69280 Marcy l'Etoile, 69007 Lyon, France. 2. CVC Clinique des Cerisioz, Route de Saint-Symphorien-d'Ozon, 69800 Lyon, France. 3. Service de Médecine interne, VetAgro Sup Campus Vétérinaire, Université de Lyon, 69280 Marcy l'Etoile, 69007 Lyon, France. 4. Laboratoire Biomnis, 17/19 avenue Tony Garnier, 69007, Lyon, France. 5. Clinique Vétérinaire de la Plage, 1 Promenade George Pompidou, 13008, Marseille, France. 6. Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, 14853, USA. 7. College of Veterinary Medicine, Cornell University, Ithaca, New York, 14853, USA.
Abstract
OBJECTIVES: To describe the clinical and pathological features of canine focal lipogranulomatous lymphangitis, to evaluate its underlying infectious cause and to compare it with human Crohn's disease. METHODS: Retrospective review of case records with a histopathological diagnosis of focal lipogranulomatous lymphangitis. Bacterial and fungal colonisation was evaluated using fluorescence in situ hybridisation and histochemical staining, respectively. A comparison with Crohn's disease was performed by a human pathologist. RESULTS: Ten dogs were evaluated. The historical complaints were predominantly chronic diarrhoea (10/10) and vomiting (5/10). The biochemical abnormalities included hypoalbuminaemia (6/10) and hypocobalaminaemia (4/6). Abdominal sonography revealed a thickened distal ileum±ileocolic junction. Colonoscopy showed a swollen caecal ostium and oedematous caecum in 7/10 dogs. A stenotic ileo-colic opening prevented endoscopic intubation in all dogs. Histology from the resected lesions revealed granulomatous inflammation involving the muscularis and serosa. Fluorescence in situ hybridization demonstrated invasive bacteria in 2/10 dogs. Post-resection, all dogs received metronidazole and tapering immunosuppressive doses of prednisolone. Remission (median 17 months) was achieved in 8/10 dogs. CLINICAL SIGNIFICANCE: Focal lipogranulomatous lymphangitis is a rare and severe form of canine inflammatory bowel disease with preferential localisation to the ileum and the ileocolic junction. An underlying infectious aetiology was not identified.
OBJECTIVES: To describe the clinical and pathological features of caninefocal lipogranulomatous lymphangitis, to evaluate its underlying infectious cause and to compare it with humanCrohn's disease. METHODS: Retrospective review of case records with a histopathological diagnosis of focal lipogranulomatous lymphangitis. Bacterial and fungal colonisation was evaluated using fluorescence in situ hybridisation and histochemical staining, respectively. A comparison with Crohn's disease was performed by a human pathologist. RESULTS: Ten dogs were evaluated. The historical complaints were predominantly chronic diarrhoea (10/10) and vomiting (5/10). The biochemical abnormalities included hypoalbuminaemia (6/10) and hypocobalaminaemia (4/6). Abdominal sonography revealed a thickened distal ileum±ileocolic junction. Colonoscopy showed a swollen caecal ostium and oedematous caecum in 7/10 dogs. A stenotic ileo-colic opening prevented endoscopic intubation in all dogs. Histology from the resected lesions revealed granulomatous inflammation involving the muscularis and serosa. Fluorescence in situ hybridization demonstrated invasive bacteria in 2/10 dogs. Post-resection, all dogs received metronidazole and tapering immunosuppressive doses of prednisolone. Remission (median 17 months) was achieved in 8/10 dogs. CLINICAL SIGNIFICANCE: Focal lipogranulomatous lymphangitis is a rare and severe form of canineinflammatory bowel disease with preferential localisation to the ileum and the ileocolic junction. An underlying infectious aetiology was not identified.
Authors: Armelle deLaforcade; Lenore Bacek; Marie-Claude Blais; Corrin Boyd; Benjamin M Brainard; Daniel L Chan; Stefano Cortellini; Robert Goggs; Guillaume L Hoareau; Amy Koenigshof; Ron Li; Alex Lynch; Alan Ralph; Elizabeth Rozanski; Claire R Sharp Journal: J Vet Emerg Crit Care (San Antonio) Date: 2022-05-02