Meng Yang1, Ling Zhang2, Linping Huang1, Xiaoliang Sun1, Haoyang Ji1, Yao Lu1. 1. a Department of Breast and Thyroid Surgery , China-Japan Friendship Hospital , Beijing , China ; 2. b Department of Nephrology , China-Japan Friendship Hospital , Beijing , China.
Abstract
BACKGROUND: Severe hypocalcemia is the most dangerous complication occurring after total parathyroidectomy without autotransplantation (TPTX) for secondary hyperparathyroidism (SHPT). We aim to identify the prevalence and potential risk factors of very severe hypocalcemia in patients with SHPT undergoing TPTX. METHODS: From April 2012 to August 2015, 157 patients with SHPT undergoing TPTX were reviewed. The critical value of hypocalcemia (CVH) was postoperative serum Ca(2+) levels of ≤1.5 mmol/L. RESULTS: Univariate analysis showed that patients in the CVH group were significantly younger than those in the non-CVH group. Sex ratio was significantly different between the two groups. The CVH group had significantly higher levels of preoperative PTH and ALP. Male sex and preoperative levels of PTH and ALP were significant independent risk factors by logistic regression analysis. CONCLUSIONS: Male sex, preoperative PTH and ALP were significantly associated with CVH in patients with SHPT undergoing TPTX.
BACKGROUND: Severe hypocalcemia is the most dangerous complication occurring after total parathyroidectomy without autotransplantation (TPTX) for secondary hyperparathyroidism (SHPT). We aim to identify the prevalence and potential risk factors of very severe hypocalcemia in patients with SHPT undergoing TPTX. METHODS: From April 2012 to August 2015, 157 patients with SHPT undergoing TPTX were reviewed. The critical value of hypocalcemia (CVH) was postoperative serum Ca(2+) levels of ≤1.5 mmol/L. RESULTS: Univariate analysis showed that patients in the CVH group were significantly younger than those in the non-CVH group. Sex ratio was significantly different between the two groups. The CVH group had significantly higher levels of preoperative PTH and ALP. Male sex and preoperative levels of PTH and ALP were significant independent risk factors by logistic regression analysis. CONCLUSIONS: Male sex, preoperative PTH and ALP were significantly associated with CVH in patients with SHPT undergoing TPTX.
Entities:
Keywords:
Chronic kidney disease; hypocalcemia; risk factors; secondary hyperparathyroidism; total parathyroidectomy without autotransplantation