Literature DB >> 27358900

Acute promyelocytic leukemia co-existing with JAK2 V617F positive myeloproliferative neoplasm: a case report.

Aleksandra Mamorska-Dyga1, Jingjing Wu1, Pallavi Khattar1, Faisal M H Ronny1, Humayun Islam1, Karen Seiter1, Delong Liu1.   

Abstract

The V617F mutation of Janus-associated kinase 2 (JAK2) is commonly seen in myeloproliferative neoplasms (MPN). Transformation of JAK2 positive MPNs to acute leukemia has been reported. We here report a case of acute promyelocytic leukemia which was later confirmed to have a co-existing JAK2 V617F positive MPN. In addition, the patient was found to have FLT3-TKD mutation, which, together with PML/RARa, could play a role in the MPN transformation to APL.

Entities:  

Keywords:  Acute myelogenous leukemia (APL); Janus-associated kinase 2 (JAK2); PML/RARa; myeloproliferative neoplasms (MPN)

Year:  2016        PMID： 27358900      PMCID： PMC4923643          DOI： 10.21037/sci.2016.03.02

Source DB:  PubMed          Journal:  Stem Cell Investig        ISSN： 2306-9759


  32 in total

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Journal:  Leukemia       Date:  2014-02-19       Impact factor: 11.528

3.  Long-term survival and blast transformation in molecularly annotated essential thrombocythemia, polycythemia vera, and myelofibrosis.

Authors:  Ayalew Tefferi; Paola Guglielmelli; Dirk R Larson; Christy Finke; Emnet A Wassie; Lisa Pieri; Naseema Gangat; Rajmonda Fjerza; Alem A Belachew; Terra L Lasho; Rhett P Ketterling; Curtis A Hanson; Alessandro Rambaldi; Guido Finazzi; Juergen Thiele; Tiziano Barbui; Animesh Pardanani; Alessandro M Vannucchi
Journal:  Blood       Date:  2014-07-18       Impact factor: 22.113

Review 4.  Acute promyelocytic leukemia developing in untreated essential thrombocythemia.

Authors:  Naoaki Sato; Tatsuo Furukawa; Masayoshi Masuko; Shigeo Hashimoto; Hidenobu Takahashi; Miyako Baba; Koichi Inano; Noriatsu Suzuki; Ken Toba; Ichiro Fuse; Yoshifusa Aizawa
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5.  How I treat myelofibrosis.

Authors:  Francisco Cervantes
Journal:  Blood       Date:  2014-09-16       Impact factor: 22.113

6.  Deregulation of apoptosis-related genes is associated with PRV1 overexpression and JAK2 V617F allele burden in Essential Thrombocythemia and Myelofibrosis.

Authors:  Raquel Tognon; Elainy P L Gasparotto; Renata P Neves; Natália S Nunes; Aline F Ferreira; Patrícia V B Palma; Simone Kashima; Dimas T Covas; Mary Santana; Elizabeth X Souto; Maria Aparecida Zanichelli; Belinda P Simões; Ana Maria de Souza; Fabíola A Castro
Journal:  J Hematol Oncol       Date:  2012-02-02       Impact factor: 17.388

Review 7.  Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases.

Authors:  Véronique Gelsi-Boyer; Mandy Brecqueville; Raynier Devillier; Anne Murati; Marie-Joelle Mozziconacci; Daniel Birnbaum
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8.  A case of minor BCR-ABL1 positive acute lymphoblastic leukemia following essential thrombocythemia and originating from a clone distinct from that harboring the JAK2-V617F mutation.

Authors:  Yuya Nagai; Masahiro Kawahara; Noriko Sugino; Yayoi Shimazu; Masakatsu Hishizawa; Kouhei Yamashita; Norimitsu Kadowaki; Akifumi Takaori-Kondo
Journal:  Exp Hematol Oncol       Date:  2014-02-17

9.  Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing.

Authors:  Andrew E O Hughes; Vincent Magrini; Ryan Demeter; Christopher A Miller; Robert Fulton; Lucinda L Fulton; William C Eades; Kevin Elliott; Sharon Heath; Peter Westervelt; Li Ding; Donald F Conrad; Brian S White; Jin Shao; Daniel C Link; John F DiPersio; Elaine R Mardis; Richard K Wilson; Timothy J Ley; Matthew J Walter; Timothy A Graubert
Journal:  PLoS Genet       Date:  2014-07-10       Impact factor: 5.917

Review 10.  Molecular genetics of chronic neutrophilic leukemia, chronic myelomonocytic leukemia and atypical chronic myeloid leukemia.

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  2 in total

1.  Acute promyelocyte leukemia arose from CALR 1 mutated post essential thrombocythemia- myelofibrosis with splanchnic vein thrombosis: A case report.

Authors:  E Morsia; G Goteri; E Torre; K B Garvey; G Discepoli; A Tassoni; S Mancini; F Giantomassi; A Poloni; A Olivieri; S Rupoli
Journal:  Leuk Res Rep       Date:  2021-05-08

2.  Myelodysplasia-related acute myeloid leukemia and acute promyelocytic leukemia: concomitant occurrence of two molecularly distinct diseases.

Authors:  Yenny Alejandra Moreno Vanegas; Abdel-Ghani M Azzouqa; David M Menke; James M Foran; Prakash Vishnu
Journal:  Hematol Rep       Date:  2018-09-05
  2 in total

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