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Literature DB >> 27358755

Poly(amido amine) dendrimers in oral delivery.

Venkata K Yellepeddi¹, Hamidreza Ghandehari².

Abstract

Poly(amidoamine) (PAMAM) dendrimers have been extensively investigated for oral delivery applications due to their ability to translocate across the gastrointestinal epithelium. In this Review, we highlight recent advances in the evaluation of PAMAM dendrimers as oral drug delivery carriers. Specifically, toxicity, mechanisms of transepithelial transport, models of the intestinal epithelial barrier including isolated human intestinal tissue model, detection of dendrimers, and surface modification are discussed. We also highlight evaluation of various PAMAM dendrimer-drug conjugates for their ability to transport across gastrointestinal epithelium for improved oral bioavailability. In addition, current challenges and future trends for clinical translation of PAMAM dendrimers as carriers for oral delivery are discussed.

Entities: Chemical Disease Species

Keywords: Caco-2 monolayer; PAMAM dendrimers; bioavailability; complexation; conjugation; cytotoxicity; permeability; translocation; ussing chamber

Mesh：

Substances：

Year: 2016 PMID： 27358755 PMCID： PMC4910834 DOI： 10.1080/21688370.2016.1173773

Source DB: PubMed Journal: Tissue Barriers ISSN： 2168-8362

64 in total

Review 1. Cell culture-based models for intestinal permeability: a critique.

Authors: Praveen V Balimane; Saeho Chong
Journal: Drug Discov Today Date: 2005-03-01 Impact factor: 7.851

2. G5-PEG PAMAM dendrimer incorporating nanostructured lipid carriers enhance oral bioavailability and plasma lipid-lowering effect of probucol.

Authors: Rong Qi; Yan-Zhi Li; Cong Chen; Yi-Ni Cao; Mao-Mao Yu; Lu Xu; Bing He; Xu Jie; Wen-Wen Shen; Yu-Nan Wang; Mallory A van Dongen; Guo-Qing Liu; Mark M Banaszak Holl; Qiang Zhang; Xue Ke
Journal: J Control Release Date: 2015-05-21 Impact factor: 9.776

Review 3. Oral drug delivery systems using chemical conjugates or physical complexes.

Authors: Taslim A Al-Hilal; Farzana Alam; Youngro Byun
Journal: Adv Drug Deliv Rev Date: 2012-12-07 Impact factor: 15.470

4. Evaluation of polyamidoamine dendrimers as potential carriers for quercetin, a versatile flavonoid.

Authors: Kanika Madaan; Viney Lather; Deepti Pandita
Journal: Drug Deliv Date: 2014-05-20 Impact factor: 6.419

Review 5. Tight junctions and the molecular basis for regulation of paracellular permeability.

Authors: J M Anderson; C M Van Itallie
Journal: Am J Physiol Date: 1995-10

6. In vitro evaluation of dendrimer prodrugs for oral drug delivery.

Authors: Mohammad Najlah; Sally Freeman; David Attwood; Antony D'Emanuele
Journal: Int J Pharm Date: 2006-11-28 Impact factor: 5.875

Review 7. Polymer therapeutics--polymers as drugs, drug and protein conjugates and gene delivery systems: past, present and future opportunities.

Authors: Ruth Duncan; Helmut Ringsdorf; Ronit Satchi-Fainaro
Journal: J Drug Target Date: 2006-07 Impact factor: 5.121

Review 8. Surface modified poly(amido)amine dendrimers as diverse nanomolecules for biomedical applications.

Authors: Venkata K Yellepeddi; Ajay Kumar; Srinath Palakurthi
Journal: Expert Opin Drug Deliv Date: 2009-08 Impact factor: 6.648

9. Transepithelial Transport of PAMAM Dendrimers Across Isolated Human Intestinal Tissue.

Authors: Dallin Hubbard; Michael Enda; Tanner Bond; Seyyed Pouya Hadipour Moghaddam; Josh Conarton; Courtney Scaife; Eric Volckmann; Hamidreza Ghandehari
Journal: Mol Pharm Date: 2015-10-12 Impact factor: 4.939

10. Intracellular Ca2+ release mediates cationic but not anionic poly(amidoamine) (PAMAM) dendrimer-induced tight junction modulation.

Authors: Brittany R Avaritt; Peter W Swaan
Journal: Pharm Res Date: 2014-03-20 Impact factor: 4.200

5 in total

Poly(amido amine) dendrimers in oral delivery.

Review 1. Cell culture-based models for intestinal permeability: a critique.

2. G5-PEG PAMAM dendrimer incorporating nanostructured lipid carriers enhance oral bioavailability and plasma lipid-lowering effect of probucol.

Review 3. Oral drug delivery systems using chemical conjugates or physical complexes.

4. Evaluation of polyamidoamine dendrimers as potential carriers for quercetin, a versatile flavonoid.

Review 5. Tight junctions and the molecular basis for regulation of paracellular permeability.

6. In vitro evaluation of dendrimer prodrugs for oral drug delivery.

Review 7. Polymer therapeutics--polymers as drugs, drug and protein conjugates and gene delivery systems: past, present and future opportunities.

Review 8. Surface modified poly(amido)amine dendrimers as diverse nanomolecules for biomedical applications.

9. Transepithelial Transport of PAMAM Dendrimers Across Isolated Human Intestinal Tissue.

10. Intracellular Ca2+ release mediates cationic but not anionic poly(amidoamine) (PAMAM) dendrimer-induced tight junction modulation.

Review 1. Let's get small (and smaller): Combining zebrafish and nanomedicine to advance neuroregenerative therapeutics.

2. Promoting Dendrimer Self-Assembly Enhances Covalent Layer-by-Layer Encapsulation of Pancreatic Islets.

Review 3. Safety Challenges and Application Strategies for the Use of Dendrimers in Medicine.

Review 4. New Advances in General Biomedical Applications of PAMAM Dendrimers.

5. Magnetically triggered drug release from nanoparticles and its applications in anti-tumor treatment.