| Literature DB >> 27358022 |
Joseph J Richardson1, Mei Y Choy2, Junling Guo1, Kang Liang1, Karen Alt2, Yuan Ping1, Jiwei Cui1, Lok S Law2, Christoph E Hagemeyer3, Frank Caruso4.
Abstract
Targeted polymer capsules can selectively bind to unstable plaques in mice after intravenous injection. Different formulations of the capsules are explored with a synthetic/biopolymer hybrid capsule showing the best stability and small-molecule drug retention. The synthetic polymer is composed of pH-sensitive blocks (PDPA), low-binding blocks (PEG), and click-groups for postfunctionalization with targeting peptides specific to plaques.Entities:
Keywords: click-chemistry; degradation; nanomedicine; polymer blends; templating
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Year: 2016 PMID： 27358022 DOI： 10.1002/adma.201601754
Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849