Literature DB >> 2735773

Calcium and calmodulin antagonism for inhibition of uterine contractions.

W Lechner1, F Keene, C Marth, J Zech.   

Abstract

In search for a new tocolytic agent we investigated felodipine, a calmodulin-antagonizing drug. Felodipine reduced the spontaneous activity of 22 uterine strips taken from the uterus in the course of a cesarean section to 52 +/- 12% (mean +/- SEM) after 10 min, to 20 +/- 7% after 20 min and to 12 +/- 4% after 60 min (P less than 0.001).

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Year:  1989        PMID： 2735773     DOI： 10.1007/bf00931290

Source DB:  PubMed          Journal:  Arch Gynecol Obstet        ISSN： 0932-0067            Impact factor:   2.344


  6 in total

1.  The interaction of felodipine with calcium-binding proteins.

Authors:  J D Johnson; C T Andrews; E J Khabbaza; J S Mills
Journal:  J Cardiovasc Pharmacol       Date:  1987       Impact factor: 3.105

2.  Interaction of the antihypertensive drug felodipine with calmodulin.

Authors:  S L Bostróm; B Ljung; S Mårdh; S Forsen; E Thulin
Journal:  Nature       Date:  1981-08-20       Impact factor: 49.962

Review 3.  Calmodulin plays a pivotal role in cellular regulation.

Authors:  W Y Cheung
Journal:  Science       Date:  1980-01-04       Impact factor: 47.728

4.  Effects of metal cations and calmodulin antagonists on [3H] nitrendipine binding in smooth and cardiac muscle.

Authors:  E M Luchowski; F Yousif; D J Triggle; S C Maurer; J G Sarmiento; R A Janis
Journal:  J Pharmacol Exp Ther       Date:  1984-09       Impact factor: 4.030

5.  Treatment of premature labor with the calcium antagonist nifedipine.

Authors:  U Ulmsten; K E Andersson; L Wingerup
Journal:  Arch Gynecol       Date:  1980-01

6.  [Uterus relaxation by highly potent Ca plus,plus-antagonistic inhibitors of electro-mechanical coupling such as Isoptin (verapamil, iproveratril), compound D 600 and Segontin (prenylamine). Experiments on the isolated virgin rat uterus].

Authors:  A Fleckenstein; G Grün; H Tritthart; K Byon
Journal:  Klin Wochenschr       Date:  1971-01
  6 in total

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