| Literature DB >> 27357427 |
Youichi Sato1, Atsushi Tajima2,3, Motoki Katsurayama1, Shiari Nozawa4, Miki Yoshiike4, Eitetsue Koh5, Jiro Kanaya5, Mikio Namiki5, Kiyomi Matsumiya6, Akira Tsujimura7, Kiyoshi Komatsu8, Naoki Itoh9, Jiro Eguchi10, Issei Imoto2, Aiko Yamauchi1, Teruaki Iwamoto4,11.
Abstract
In men, follicle-stimulating hormone (FSH) acts on the seminiferous tubules and enhances spermatogenesis. Recently, a candidate locus (rs2414095) for FSH levels was identified by a genome-wide association study (GWAS) in Chinese men. The rs2414095 single-nucleotide polymorphism (SNP) is found on the third intron of the cytochrome P450, family 19, subfamily A, peptide 1 (CYP19A1) gene encoding an aromatase. In the present study, we performed a replication study in 1687 Japanese men (901 from cohort 1 and 786 from cohort 2) to assess whether this SNP is associated with circulating FSH levels. Furthermore, we investigated whether the rs2414095 SNP is correlated with semen quality traits in 2015 Japanese men (1224 from cohort 1 and 791 from cohort 2). The rs2414095 SNP was significantly associated with circulating FSH levels (βSTD=0.15, P=9.7 × 10-5), sperm concentration (βSTD=0.073, P=0.032) and total sperm number (TSN) (βSTD=0.074, P=0.027) in a combined analysis of the two Japanese male cohorts. We successfully replicated, in Japanese men, the results of the previous GWAS for the rs2414095 SNP in Chinese men, and found that the rs2414095 SNP was related with sperm production.Entities:
Mesh：
Substances：
Year: 2016 PMID： 27357427 DOI： 10.1038/jhg.2016.82
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172