Rolf Jorde1,2, Stina T Sollid1,2, Johan Svartberg1,2, Ragnar M Joakimsen1,2, Guri Grimnes1,2, Moira Y S Hutchinson3. 1. a Department of Clinical Medicine , Tromsø Endocrine Research Group, UiT The Arctic University of Norway , Tromsø , Norway ; 2. b Division of Internal Medicine , University Hospital of North Norway , Tromsø , Norway ; 3. c Division of Head and Motion, Department of Rheumatology , Nordland Hospital , Bodø , Norway.
Abstract
BACKGROUND: In observational studies vitamin D deficiency is associated with increased risk of infections, whereas the effect of vitamin D supplementation in randomized controlled trials is non-conclusive. METHODS:Five hundred and eleven subjects with prediabetes were randomized to vitamin D3 (20,000 IU per week) versus placebo for five years. Every sixth month, a questionnaire on respiratory tract infections (RTI) (common cold, bronchitis, influenza) and urinary tract infection (UTI) was filled in. RESULTS:Mean baseline serum 25-hydroxyvitamin D (25(OH)D) level was 60 nmol/L. Two hundred and fifty-six subjects receivedvitamin D and 255 placebo. One hundred and sixteen subjects in the vitamin D and 111 in theplacebo group completed the five-year study. Eighteen subjects in the vitamin D group and 34 subjects in the placebo group reported UTI during the study (p < 0.02), whereas no significant differences were seen for RTI. The effect on UTI was most pronounced in males. The effect of vitamin D on UTI was unrelated to baseline serum 25(OH)D level. CONCLUSION: Supplementation with vitamin D might prevent UTI, but confirmatory studies are needed.
RCT Entities:
BACKGROUND: In observational studies vitamin D deficiency is associated with increased risk of infections, whereas the effect of vitamin D supplementation in randomized controlled trials is non-conclusive. METHODS: Five hundred and eleven subjects with prediabetes were randomized to vitamin D3 (20,000 IU per week) versus placebo for five years. Every sixth month, a questionnaire on respiratory tract infections (RTI) (common cold, bronchitis, influenza) and urinary tract infection (UTI) was filled in. RESULTS: Mean baseline serum 25-hydroxyvitamin D (25(OH)D) level was 60 nmol/L. Two hundred and fifty-six subjects received vitamin D and 255 placebo. One hundred and sixteen subjects in the vitamin D and 111 in the placebo group completed the five-year study. Eighteen subjects in the vitamin D group and 34 subjects in the placebo group reported UTI during the study (p < 0.02), whereas no significant differences were seen for RTI. The effect on UTI was most pronounced in males. The effect of vitamin D on UTI was unrelated to baseline serum 25(OH)D level. CONCLUSION: Supplementation with vitamin D might prevent UTI, but confirmatory studies are needed.
Entities:
Keywords:
Diabetes; respiratory infection; urinary tract infection; vitamin D
Authors: Ahmed S Safwat; Ahmad Hasanain; Ahmed Shahat; Mostafa AbdelRazek; Hazem Orabi; Samir K Abdul Hamid; Amany Nafee; Sally Bakkar; Mohamed Sayed Journal: World J Urol Date: 2018-10-25 Impact factor: 4.226