Literature DB >> 27357076

Nickel-Catalyzed Reductive Amidation of Unactivated Alkyl Bromides.

Eloisa Serrano1, Ruben Martin2,3.   

Abstract

A user-friendly, nickel-catalyzed reductive amidation of unactivated primary, secondary, and tertiary alkyl bromides with isocyanates is described. This catalytic strategy offers an efficient synthesis of a wide range of aliphatic amides under mild conditions and with an excellent chemoselectivity profile while avoiding the use of stoichiometric and sensitive organometallic reagents.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  cross-coupling; nickel; reductive coupling; synthetic methods

Year:  2016        PMID： 27357076     DOI： 10.1002/anie.201605162

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  7 in total

1.  Synthesis of Tetrasubstituted Alkenes by Tandem Metallacycle Formation/Cross-Electrophile Coupling.

Authors:  Kirk W Shimkin; John Montgomery
Journal:  J Am Chem Soc       Date:  2018-05-31       Impact factor: 15.419

2.  Synthesis and Reactivity of Paramagnetic Nickel Polypyridyl Complexes Relevant to C(sp2 )-C(sp3 )Coupling Reactions.

Authors:  Megan Mohadjer Beromi; Gary W Brudvig; Nilay Hazari; Hannah M C Lant; Brandon Q Mercado
Journal:  Angew Chem Int Ed Engl       Date:  2019-03-27       Impact factor: 15.336

3.  Cobalt-Catalyzed Aminocarbonylation of Alkyl Tosylates: Stereospecific Synthesis of Amides.

Authors:  Brendon T Sargent; Erik J Alexanian
Journal:  Angew Chem Int Ed Engl       Date:  2019-06-05       Impact factor: 15.336

4.  Nickel/Photoredox-Catalyzed Amidation via Alkylsilicates and Isocyanates.

Authors:  Shuai Zheng; David N Primer; Gary A Molander
Journal:  ACS Catal       Date:  2017-10-25       Impact factor: 13.084

5.  Direct amidation of esters with nitroarenes.

Authors:  Chi Wai Cheung; Marten Leendert Ploeger; Xile Hu
Journal:  Nat Commun       Date:  2017-03-27       Impact factor: 14.919

6.  Amide synthesis via nickel-catalysed reductive aminocarbonylation of aryl halides with nitroarenes.

Authors:  Chi Wai Cheung; Marten Leendert Ploeger; Xile Hu
Journal:  Chem Sci       Date:  2017-11-06       Impact factor: 9.825

7.  Nickel-catalyzed reductive thiolation and selenylation of unactivated alkyl bromides.

Authors:  Yi Fang; Torben Rogge; Lutz Ackermann; Shun-Yi Wang; Shun-Jun Ji
Journal:  Nat Commun       Date:  2018-06-08       Impact factor: 14.919
  7 in total

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