Hirotoshi Kobayashi1,2, Hideyuki Ishida3,4, Hideki Ueno3,5, Takao Hinoi3,6, Yasuhiro Inoue3,7, Fumio Ishida3,8, Yukihide Kanemitsu3,9, Tsuyoshi Konishi3,10, Tatsuro Yamaguchi3,11, Naohiro Tomita3,12, Nagahide Matsubara3,12, Toshiaki Watanabe3,13, Kenichi Sugihara3,14. 1. Department of Surgery, Tokyo Metropolitan Hiroo Hospital, 2-34-10 Ebisu, Shibuya-ku, Tokyo, 150-0013, Japan. h-kobayashi.srg2@tmd.ac.jp. 2. Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan. h-kobayashi.srg2@tmd.ac.jp. 3. Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum, Tokyo, Japan. 4. Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan. 5. Department of Surgery, National Defense Medical College, Saitama, Japan. 6. Department of Surgery and Institute for Clinical Research, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan. 7. Department of Gastrointestinal and Pediatric Surgery, Mie University, Graduate School of Medicine, Mie, Japan. 8. Digestive Disease Center, Northern Yokohama Hospital, Showa University, Yokohama, Japan. 9. Colorectal Surgery Division, National Cancer Center Hospital, Tokyo, Japan. 10. Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan. 11. Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan. 12. Department of Surgery, Hyogo College of Medicine, Hyogo, Japan. 13. Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. 14. Tokyo Medical and Dental University, Tokyo, Japan.
Abstract
PURPOSE: Familial adenomatous polyposis (FAP) is a genetic disorder. Some female patients with FAP can become pregnant. However, the current state of childbirth after surgery for FAP is unclear in Japan. METHODS: The study investigated 303 patients (147 female) who had undergone surgery for FAP at the 23 institutions between 2000 and 2012. RESULTS: Eighty female patients had information available on childbirth after surgery for FAP. Eight patients (10 %) gave birth after surgery. The mean age at surgery for FAP was 27 (range 20-41) years and 37 years in patients with and without childbirth after surgery, respectively (P = 0.044). The rate of childbirth after surgery was 17 % in women ≤30 years of age and 13 % in those ≤40 years of age. Although only one patient with invasive cancer (2.9 %) gave childbirth after surgery, seven patients without cancer (15.6 %) gave birth (P = 0.045). CONCLUSIONS: This study clarified the current state of childbirth after surgery for FAP in Japan. It is important to use these data to determine the best therapeutic approach for female FAP patients.
PURPOSE:Familial adenomatous polyposis (FAP) is a genetic disorder. Some female patients with FAP can become pregnant. However, the current state of childbirth after surgery for FAP is unclear in Japan. METHODS: The study investigated 303 patients (147 female) who had undergone surgery for FAP at the 23 institutions between 2000 and 2012. RESULTS: Eighty female patients had information available on childbirth after surgery for FAP. Eight patients (10 %) gave birth after surgery. The mean age at surgery for FAP was 27 (range 20-41) years and 37 years in patients with and without childbirth after surgery, respectively (P = 0.044). The rate of childbirth after surgery was 17 % in women ≤30 years of age and 13 % in those ≤40 years of age. Although only one patient with invasive cancer (2.9 %) gave childbirth after surgery, seven patients without cancer (15.6 %) gave birth (P = 0.045). CONCLUSIONS: This study clarified the current state of childbirth after surgery for FAP in Japan. It is important to use these data to determine the best therapeutic approach for female FAP patients.
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