Anders Rönnblom1, Tommy Holmström2, Hans Tanghöj3, Urban Karlbom4, Mari Thörn1, Daniel Sjöberg5. 1. a Department of Medical Sciences , Uppsala University , Uppsala , Sweden ; 2. b Department of Internal Medicine , Mariehamn , Finland , Åland ; 3. c Department of Internal Medicine , Mälar Hospital , Eskilstuna , Sweden ; 4. d Department of Surgery , Uppsala University , Uppsala , Sweden ; 5. e Department of Internal Medicine , Falu Hospital , Falun , Sweden.
Abstract
OBJECTIVE: The medical treatment of ulcerative colitis (UC) has seen a change towards a more active attitude during recent years, including both the use of more traditional drugs as well as new biological substances. In this epidemiological study we have evaluated the results of modern treatment of UC in a population-based cohort of patients including all age groups, with regard to relapse rate, colectomy and IBD-associated mortality. MATERIAL AND METHODS: Patients diagnosed with UC in the Uppsala health care region in the middle of Sweden during 2005-2009 were included in the study. Out of 524 patients, 491 (93%) could be followed for five full years or until death. RESULTS: Nineteen patients (3.9%) had died and two of these deaths could be attributed to UC (one postoperative death and one colonic carcinoma). The following drugs were used by the patients during the study period: 5-ASA (91%), systemic steroids (66%), immunomodulators (IMM), mainly thiopurines (26%) and anti-TNF (11%). During the observation period, 74% experienced at least one relapse and 5.3% were subjected to colectomy. Among patients <17 years at diagnosis, colectomy was performed in two (4.8%). CONCLUSIONS: Five years after diagnosis of ulcerative colitis, 5.3% had been subjected to colectomy and two patients (0.38%) had died because of the disease.
OBJECTIVE: The medical treatment of ulcerative colitis (UC) has seen a change towards a more active attitude during recent years, including both the use of more traditional drugs as well as new biological substances. In this epidemiological study we have evaluated the results of modern treatment of UC in a population-based cohort of patients including all age groups, with regard to relapse rate, colectomy and IBD-associated mortality. MATERIAL AND METHODS:Patients diagnosed with UC in the Uppsala health care region in the middle of Sweden during 2005-2009 were included in the study. Out of 524 patients, 491 (93%) could be followed for five full years or until death. RESULTS: Nineteen patients (3.9%) had died and two of these deaths could be attributed to UC (one postoperative death and one colonic carcinoma). The following drugs were used by the patients during the study period: 5-ASA (91%), systemic steroids (66%), immunomodulators (IMM), mainly thiopurines (26%) and anti-TNF (11%). During the observation period, 74% experienced at least one relapse and 5.3% were subjected to colectomy. Among patients <17 years at diagnosis, colectomy was performed in two (4.8%). CONCLUSIONS: Five years after diagnosis of ulcerative colitis, 5.3% had been subjected to colectomy and two patients (0.38%) had died because of the disease.
Authors: Mohamed Elbadry; Mohamed O Nour; Mohamed Hussien; Elsayed Awad Ghoneem; Mohammed A Medhat; Hany Shehab; Sherif Galal; Mohamed Eltabbakh; Fathiya El-Raey; Mohamed Negm; Shimaa Afify; Walaa Abdelhamed; Ahmed Sherief; Ahmed Abdelaziz; Mohamed Abo Elkasem; Aya Mahrous; Ghada Kamal; Maha Maher; Omar Abdel-Hameed; Abubakr Elbasuny; Islam El-Zayyadi; Ahmed Bassiony; Abdelmajeed Moussa; Essam Bedewy; Asem Elfert; Mohamed El Kassas Journal: Front Med (Lausanne) Date: 2022-04-19
Authors: Lester Tsai; Christopher Ma; Parambir S Dulai; Larry J Prokop; Samuel Eisenstein; Sonia L Ramamoorthy; Brian G Feagan; Vipul Jairath; William J Sandborn; Siddharth Singh Journal: Clin Gastroenterol Hepatol Date: 2020-10-27 Impact factor: 13.576