Angela Ding1, Javier Elizalde2, Rafael Ignacio Barraquer2. 1. Centro de Oftalmología Barraquer, Barcelona, Spain. 2. Centro de Oftalmología Barraquer, Barcelona, Spain; Ocular Oncology Service, Barcelona, Spain; Universitat Internacional de Catalunya (UIC), Barcelona, Spain.
Abstract
BACKGROUND/AIMS: The aim of our study was to report a case of progression of cutaneous vitiligo after large posterior choroidal melanoma diagnosis. METHODS: The clinical history, fundus findings and histopathological features suggest the diagnosis of cutaneous vitiligous progression after a diagnosis of large posterior choroidal melanoma. RESULTS: A 30-year-old female, with a personal history of cutaneous vitiligo for 12 years, was diagnosed with choroidal melanoma 18 months previously. The cutaneous vitiligo had progressed over her back, body and arms during the preceding 3 years. She refused treatment because she was in her 28th week of pregnancy. When she came to our clinic her visual symptoms had worsened, and the fundus examination showed a melanocytic choroidal mass. After confirming that there was no extraocular extension, she was treated with enucleation. A histopathological study confirmed the choroidal melanoma diagnosis. CONCLUSION: The association between the progression of vitiligo and the diagnosis of uveal melanoma could be considered a good prognostic factor, as has been described in cases of cutaneous melanoma. A longer follow-up of these patients will allow us to confirm this association.
BACKGROUND/AIMS: The aim of our study was to report a case of progression of cutaneous vitiligo after large posterior choroidal melanoma diagnosis. METHODS: The clinical history, fundus findings and histopathological features suggest the diagnosis of cutaneous vitiligous progression after a diagnosis of large posterior choroidal melanoma. RESULTS: A 30-year-old female, with a personal history of cutaneous vitiligo for 12 years, was diagnosed with choroidal melanoma 18 months previously. The cutaneous vitiligo had progressed over her back, body and arms during the preceding 3 years. She refused treatment because she was in her 28th week of pregnancy. When she came to our clinic her visual symptoms had worsened, and the fundus examination showed a melanocytic choroidal mass. After confirming that there was no extraocular extension, she was treated with enucleation. A histopathological study confirmed the choroidal melanoma diagnosis. CONCLUSION: The association between the progression of vitiligo and the diagnosis of uveal melanoma could be considered a good prognostic factor, as has been described in cases of cutaneous melanoma. A longer follow-up of these patients will allow us to confirm this association.
Authors: M A Chang; G Fournier; H K Koh; A J Sober; H Nakagawa; T B Fitzpatrick; D M Albert Journal: Graefes Arch Clin Exp Ophthalmol Date: 1986 Impact factor: 3.117
Authors: P Quaglino; F Marenco; S Osella-Abate; N Cappello; M Ortoncelli; B Salomone; M T Fierro; P Savoia; M G Bernengo Journal: Ann Oncol Date: 2009-07-21 Impact factor: 32.976