| Literature DB >> 27354356 |
David Sacerdoti1, Paola Pesce2, Marco Di Pascoli1, Massimo Bolognesi1.
Abstract
Epoxygenase-dependent metabolites of arachidonc acid, EETs and the heme-oxygenase (HO)-1/carbon monoxide/bilverdin system share similarities in their activity and mediators. They control endothelial function, dilating small arterial vessels, decrease blood pressure, protect the heart from ischemic and hypertensive cardiopathy, control renal circulation and function, promote angiogenesis and organ regeneration, oppose oxidative stress and inflammation, improve diabetes and obesity, have protective effects on the liver, and participate in portal hypertension. Furthermore, EETs induce HO-1, and inhibition of HO-1 abolishes most of the effects of EETs. Thus, a close interaction between the two systems exists, and is relevant in view of their therapeutic potential.Entities:
Keywords: AA; Arachidonic acid; CO; Carbon monoxide; Diabetes; EET; Epoxyeicosatrienoic acid; HO-1; Heme oxygenase; Hypertension; Myocardial infarction; NAFLD
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Year: 2016 PMID： 27354356 DOI： 10.1016/j.prostaglandins.2016.06.002
Source DB: PubMed Journal: Prostaglandins Other Lipid Mediat ISSN： 1098-8823 Impact factor: 3.072