Jun Sasahara1, Keisuke Ishii2, Nagayoshi Umehara3, Mari Oba4, Kenji Kiyoshi5, Takeshi Murakoshi6, Tomohiro Tanemoto7, Hiroshi Ishikawa8, Kiyotake Ichizuka9, Aya Yoshida3, Kei Tanaka10, Katsusuke Ozawa11, Haruhiko Sago3. 1. Department of Maternal Fetal Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Japan. 2. Department of Maternal Fetal Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Japan. keisui@mch.pref.osaka.jp. 3. Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan. 4. Department of Medical Statistics, Faculty of Medicine, Toho University, Yokohama, Japan. 5. Department of Obstetrics, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan. 6. Maternal and Perinatal Care Center, Seirei Hamamatsu General Hospital, Hamamatsu, Japan. 7. Department of Obstetrics and Gynecology, Jikei University School of Medicine, Tokyo, Japan. 8. Department of Obstetrics, Kanagawa Children's Medical Center, Yokohama, Japan. 9. Department of Obstetrics and Gynecology, Showa University, Tokyo, Japan. 10. Department of Obstetrics and Gynecology, Kyorin University, Tokyo, Japan. 11. Department of Obstetrics, Miyagi Children's Hospital, Sendai, Japan.
Abstract
AIM: The aim of this study was to evaluate the association between oligohydramnios and other perinatal factors in preterm small-for-gestational-age (SGA) infants who had cerebral palsy at 18 months of age or who had died before this age. METHODS: This retrospective study included 320 infants with birthweights < 3rd percentile delivered between 22 and 33 complete weeks of gestation. We evaluated the incidence of CP at 18 months of age and of death before this age. The significant risk factors, including oligohydramnios, of CP or death of preterm SGA infants were evaluated by logistic regression analysis. RESULTS: The incidence of CP or death was 47/320 (14.7%), consisting of 24/320 (7.5%) cases of CP and 23/320 (7.2%) cases of death. Oligohydramnios (adjusted odds ratio, 2.18; 95% confidence interval, 1.07-4.45) and gestational age (adjusted odds ratio, 0.76; 95% confidence interval, 0.66-0.87) were independently correlated with outcome. CONCLUSION: The incidence of adverse outcomes was approximately 15% in preterm SGA infants. SGA infants born with oligohydramnios may be at increased risk for CP or death compared to those with normal amniotic volume.
AIM: The aim of this study was to evaluate the association between oligohydramnios and other perinatal factors in preterm small-for-gestational-age (SGA) infants who had cerebral palsy at 18 months of age or who had died before this age. METHODS: This retrospective study included 320 infants with birthweights < 3rd percentile delivered between 22 and 33 complete weeks of gestation. We evaluated the incidence of CP at 18 months of age and of death before this age. The significant risk factors, including oligohydramnios, of CP or death of preterm SGA infants were evaluated by logistic regression analysis. RESULTS: The incidence of CP or death was 47/320 (14.7%), consisting of 24/320 (7.5%) cases of CP and 23/320 (7.2%) cases of death. Oligohydramnios (adjusted odds ratio, 2.18; 95% confidence interval, 1.07-4.45) and gestational age (adjusted odds ratio, 0.76; 95% confidence interval, 0.66-0.87) were independently correlated with outcome. CONCLUSION: The incidence of adverse outcomes was approximately 15% in preterm SGA infants. SGA infants born with oligohydramnios may be at increased risk for CP or death compared to those with normal amniotic volume.