| Literature DB >> 27352778 |
Elham Ahmadian1,2,3,4, Peter S Pennefather5, Aziz Eftekhari1,4, Reza Heidari6,7, Mohammad Ali Eghbal1,2,3.
Abstract
INTRODUCTION: The current review aimed to outline the functions of the renin angiotensin system (RAS) in the context of the oxidative stress-associated liver disease. Areas covered: Angiotensin II (Ang II) as the major effector peptide of the RAS is a pro-oxidant and fibrogenic cytokine. Mechanistically, NADPH oxidase (NOX) is a multicomponent enzyme complex that is able to generate reactive oxygen species (ROS) as a downstream signaling pathway of Ang II which is expressed in liver. Ang II has a detrimental role in the pathogenesis of chronic liver disease through possessing pro-oxidant, fibrogenic, and pro-inflammatory impact in the liver. The alternative axis (ACE2/Ang(1-7)/mas) of the RAS serves as an anti-inflammatory, antioxidant and anti-fibrotic component of the RAS. Expert commentary: In summary, the use of alternative axis inhibitors accompanying with ACE2/ Ang(1-7)/mas axis activation is a promising new strategy serving as a novel therapeutic option to prevent and treat chronic liver diseases.Entities:
Keywords: NADPH oxidase; Renin–angiotensin system; angiotensin II; angiotensin converting enzyme inhibitor; angiotensin receptor blocker; anti-oxidant; liver disease; oxidative stress
Mesh：
Substances：
Year: 2016 PMID： 27352778 DOI： 10.1080/17474124.2016.1207523
Source DB: PubMed Journal: Expert Rev Gastroenterol Hepatol ISSN： 1747-4124 Impact factor: 3.869