| Literature DB >> 27352640 |
Marciana Sanabria1, Maira Smaniotto Cucielo2, Marina Trevizan Guerra2, Cibele Dos Santos Borges2, Thais Petrochelli Banzato2, Juliana Elaine Perobelli2, Gabriel Adan Araújo Leite2, Janete Aparecida Anselmo-Franci3, Wilma De Grava Kempinas2.
Abstract
Exposure to Tetrachlorodibenzo-p-dioxin (TCDD) in male rats promotes, decreased sperm concentration, alterations in motility and in sperm transit time. We evaluated the effect transgenerational of in utero exposure to low doses TCDD in the sperm quality. Pregnant rats (F0) were exposed to 0.1; 0.5 and 1.0μg of TCDD, on gestational day 15, coincides with the end of most organogenesis in the fetus. Adult male offspring (F1, F2 and F3 generation) were investigated for fertility after artificial insemination in utero. After collection of the uterus and ovaries, the numbers of corpora lutea and implants were determined. TCDD provoked alterations in sperm morphology and diminution in serum testosterone levels and sperm transit time in the cauda epididymis. The fertility significantly decreased in all the generations, at least at one dose. In conclusion, TCDD exposure decreases rat sperm quality and fertility in adult male offspring and this effects persist into the next generation.Entities:
Keywords: Dioxin; Epididymis; Fertility; Sperm quality; Transgenerational effect
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Year: 2016 PMID： 27352640 DOI： 10.1016/j.reprotox.2016.06.019
Source DB: PubMed Journal: Reprod Toxicol ISSN： 0890-6238 Impact factor: 3.143