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Literature DB >> 2735189

Altered levels of microtubule proteins in brains of Alzheimer's disease patients.

A Nieto¹, E Montejo de Garcini, J Avila.

Abstract

The amount of microtubule protein present in the total soluble protein from brains of Alzheimer's disease patients and from brains of non-Alzheimer age-matched controls, were determined by radioimmunoassay. No differences were found in the amount of tubulin or microtubule-associated protein MAP2 present in either group. However, the amount of tau protein or MAP1 from the brains of Alzheimer's disease patients was about half of that present in their control counterparts.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2735189 DOI： 10.1007/bf00687401

Source DB: PubMed Journal: Acta Neuropathol ISSN： 0001-6322 Impact factor: 17.088

25 in total

1. Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

Authors: K S Kosik; C L Joachim; D J Selkoe
Journal: Proc Natl Acad Sci U S A Date: 1986-06 Impact factor: 11.205

2. Quantitation and characterization of tau factor in porcine tissues.

Authors: E Montejo de Garcini; J C Díez; J Avila
Journal: Biochim Biophys Acta Date: 1986-05-02

3. Role of microtubules in the distribution of the Golgi apparatus: effect of taxol and microinjected anti-alpha-tubulin antibodies.

Authors: J Wehland; M Henkart; R Klausner; I V Sandoval
Journal: Proc Natl Acad Sci U S A Date: 1983-07 Impact factor: 11.205

4. Differences in the cellular distributions of two microtubule-associated proteins, MAP1 and MAP2, in rat brain.

Authors: G Huber; A Matus
Journal: J Neurosci Date: 1984-01 Impact factor: 6.167

5. Identification of human Sm and (U1) RNP antigens by immunoblotting.

Authors: H H Guldner; H J Lakomek; F A Bautz
Journal: J Immunol Methods Date: 1983-11-11 Impact factor: 2.303

6. Involvement of the carboxyl-terminal domain of tubulin in the regulation of its assembly.

Authors: L Serrano; J de la Torre; R B Maccioni; J Avila
Journal: Proc Natl Acad Sci U S A Date: 1984-10 Impact factor: 11.205

7. Quantitation and characterization of the microtubule associated MAP2 in porcine tissues and its isolation from porcine (PK15) and human (HeLa) cell lines.

Authors: M M Valdivia; J Avila; J Coll; C Colaço; I V Sandoval
Journal: Biochem Biophys Res Commun Date: 1982-04-29 Impact factor: 3.575

8. Quantitative evidence for selective dendritic growth in normal human aging but not in senile dementia.

Authors: S J Buell; P D Coleman
Journal: Brain Res Date: 1981-06-09 Impact factor: 3.252

9. Microtubule-associated protein 2: monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles.

Authors: K S Kosik; L K Duffy; M M Dowling; C Abraham; A McCluskey; D J Selkoe
Journal: Proc Natl Acad Sci U S A Date: 1984-12 Impact factor: 11.205

10. Tau protein function in living cells.

Authors: D G Drubin; M W Kirschner
Journal: J Cell Biol Date: 1986-12 Impact factor: 10.539

4 in total

1. Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.

Authors: Qiu-Lan Ma; Xiaohong Zuo; Fusheng Yang; Oliver J Ubeda; Dana J Gant; Mher Alaverdyan; Nicolae C Kiosea; Sean Nazari; Ping Ping Chen; Fatiha Nothias; Piu Chan; Edmond Teng; Sally A Frautschy; Greg M Cole
Journal: J Neurosci Date: 2014-05-21 Impact factor: 6.167