Literature DB >> 27351588

Macrophages and inflammatory mediators in pulmonary injury induced by mustard vesicants.

Rama Malaviya1, Vasanthi R Sunil1, Alessandro Venosa1, Kinal N Vayas1, Rita Businaro2, Diane E Heck3, Jeffrey D Laskin4, Debra L Laskin1.   

Abstract

Sulfur mustard (SM) and nitrogen mustard (NM) are cytotoxic alkylating agents that cause severe and progressive injury to the respiratory tract, resulting in significant morbidity and mortality. Evidence suggests that macrophages and the inflammatory mediators they release play roles in both acute and long-term pulmonary injuries caused by mustards. In this article, we review the pathogenic effects of SM and NM on the respiratory tract and potential inflammatory mechanisms contributing to this activity.
© 2016 New York Academy of Sciences.

Entities:  

Keywords:  inflammatory mediators; macrophages; mustards; pulmonary toxicity

Mesh：

Substances：

Year:  2016        PMID： 27351588      PMCID： PMC5119480          DOI： 10.1111/nyas.13123

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  62 in total

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  6 in total

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