Literature DB >> 27350445

New MAPS for misfolded proteins.

Norbert Volkmar1, Emma Fenech1, John C Christianson1.   

Abstract

Clearing misfolded proteins from the cytoplasm is essential to maintain cellular homeostasis. Now, a parallel clearance system is described that uses the deubiquitylase USP19 to enable secretion of misfolded cytoplasmic proteins when conventional proteasomal degradation is compromised. Misfolding-associated protein secretion (MAPS) has important implications for protein quality control and prion-like transmission.

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Year:  2016        PMID： 27350445     DOI： 10.1038/ncb3381

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  15 in total

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Journal:  Curr Opin Biotechnol       Date:  2010-07-14       Impact factor: 9.740

2.  Characterization of the deubiquitinating activity of USP19 and its role in endoplasmic reticulum-associated degradation.

Authors:  Jin-Gu Lee; Woong Kim; Steven Gygi; Yihong Ye
Journal:  J Biol Chem       Date:  2013-12-19       Impact factor: 5.157

3.  Rab7 and Rab9 are recruited onto late endosomes by biochemically distinguishable processes.

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Journal:  J Biol Chem       Date:  1995-10-27       Impact factor: 5.157

4.  Cell biology. Unconventional secretion, unconventional solutions.

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Journal:  Science       Date:  2013-05-03       Impact factor: 47.728

5.  Unconventional secretion of misfolded proteins promotes adaptation to proteasome dysfunction in mammalian cells.

Authors:  Jin-Gu Lee; Shokichi Takahama; Guofeng Zhang; Stanislav I Tomarev; Yihong Ye
Journal:  Nat Cell Biol       Date:  2016-06-13       Impact factor: 28.824

6.  Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease.

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Review 7.  Extracellular α--synuclein-a novel and crucial factor in Lewy body diseases.

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8.  The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates.

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Journal:  EMBO Rep       Date:  2009-05-22       Impact factor: 8.807

Review 9.  Protein Transmission, Seeding and Degradation: Key Steps for α-Synuclein Prion-Like Propagation.

Authors:  Abid Oueslati; Methodios Ximerakis; Kostas Vekrellis
Journal:  Exp Neurobiol       Date:  2014-12-12       Impact factor: 3.261

Review 10.  Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.

Authors:  Aaron Ciechanover; Yong Tae Kwon
Journal:  Exp Mol Med       Date:  2015-03-13       Impact factor: 8.718
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Review 4.  Modulation of ERQC and ERAD: A Broad-Spectrum Spanner in the Works of Cancer Cells?

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