Literature DB >> 27350444

p21 shapes cancer evolution.

Vasily S Romanov1, K Lenhard Rudolph1.   

Abstract

Although known to induce cellular senescence, an important tumour suppressor mechanism, mutation of CDKN1A - the gene encoding p21 (also known as WAF1 or CIP1) - is rare in human cancers. Now, a study reports a previously unappreciated oncogenic effect of p21 overexpression that shapes cancer genome evolution through induction of replication stress.

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Year:  2016        PMID： 27350444     DOI： 10.1038/ncb3382

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  15 in total

1.  High-intensity p38 kinase activity is critical for p21(cip1) induction and the antiproliferative function of G(i) protein-coupled receptors.

Authors:  F Alderton; P P Humphrey; L A Sellers
Journal:  Mol Pharmacol       Date:  2001-05       Impact factor: 4.436

Review 2.  Cyclin-dependent kinase inhibitor p21(Waf1): contemporary view on its role in senescence and oncogenesis.

Authors:  V S Romanov; V A Pospelov; T V Pospelova
Journal:  Biochemistry (Mosc)       Date:  2012-06       Impact factor: 2.487

3.  Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing.

Authors:  Panagiotis Galanos; Konstantinos Vougas; David Walter; Alexander Polyzos; Apolinar Maya-Mendoza; Emma J Haagensen; Antonis Kokkalis; Fani-Marlen Roumelioti; Sarantis Gagos; Maria Tzetis; Begoña Canovas; Ana Igea; Akshay K Ahuja; Ralph Zellweger; Sofia Havaki; Emanuel Kanavakis; Dimitris Kletsas; Igor B Roninson; Spiros D Garbis; Massimo Lopes; Angel Nebreda; Dimitris Thanos; J Julian Blow; Paul Townsend; Claus Storgaard Sørensen; Jiri Bartek; Vassilis G Gorgoulis
Journal:  Nat Cell Biol       Date:  2016-06-20       Impact factor: 28.824

4.  Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence.

Authors:  Tongyuan Li; Ning Kon; Le Jiang; Minjia Tan; Thomas Ludwig; Yingming Zhao; Richard Baer; Wei Gu
Journal:  Cell       Date:  2012-06-08       Impact factor: 41.582

Review 5.  Biology of the cell cycle inhibitor p21(CDKN1A): molecular mechanisms and relevance in chemical toxicology.

Authors:  Ilaria Dutto; Micol Tillhon; Ornella Cazzalini; Lucia A Stivala; Ennio Prosperi
Journal:  Arch Toxicol       Date:  2014-12-17       Impact factor: 5.153

Review 6.  Regulation of PCNA-protein interactions for genome stability.

Authors:  Niels Mailand; Ian Gibbs-Seymour; Simon Bekker-Jensen
Journal:  Nat Rev Mol Cell Biol       Date:  2013-04-18       Impact factor: 94.444

7.  In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.

Authors:  Ramona Rudalska; Daniel Dauch; Thomas Longerich; Katherine McJunkin; Torsten Wuestefeld; Tae-Won Kang; Anja Hohmeyer; Marina Pesic; Josef Leibold; Anne von Thun; Peter Schirmacher; Johannes Zuber; Karl-Heinz Weiss; Scott Powers; Nisar P Malek; Martin Eilers; Bence Sipos; Scott W Lowe; Robert Geffers; Stefan Laufer; Lars Zender
Journal:  Nat Med       Date:  2014-09-14       Impact factor: 53.440

8.  Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.

Authors:  Andrea Viale; Francesca De Franco; Annette Orleth; Valeria Cambiaghi; Virginia Giuliani; Daniela Bossi; Chiara Ronchini; Simona Ronzoni; Ivan Muradore; Silvia Monestiroli; Alberto Gobbi; Myriam Alcalay; Saverio Minucci; Pier Giuseppe Pelicci
Journal:  Nature       Date:  2009-01-01       Impact factor: 49.962

9.  Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin.

Authors:  Iñigo Martincorena; Amit Roshan; Moritz Gerstung; Peter Ellis; Peter Van Loo; Stuart McLaren; David C Wedge; Anthony Fullam; Ludmil B Alexandrov; Jose M Tubio; Lucy Stebbings; Andrew Menzies; Sara Widaa; Michael R Stratton; Philip H Jones; Peter J Campbell
Journal:  Science       Date:  2015-05-22       Impact factor: 47.728

10.  Replication stress links structural and numerical cancer chromosomal instability.

Authors:  Rebecca A Burrell; Sarah E McClelland; David Endesfelder; Petra Groth; Marie-Christine Weller; Nadeem Shaikh; Enric Domingo; Nnennaya Kanu; Sally M Dewhurst; Eva Gronroos; Su Kit Chew; Andrew J Rowan; Arne Schenk; Michal Sheffer; Michael Howell; Maik Kschischo; Axel Behrens; Thomas Helleday; Jiri Bartek; Ian P Tomlinson; Charles Swanton
Journal:  Nature       Date:  2013-02-28       Impact factor: 49.962
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  9 in total

1.  Tumor-suppressive effect of S-adenosylmethionine supplementation in a murine model of inflammation-mediated hepatocarcinogenesis is dependent on treatment longevity.

Authors:  Evgeniy Stoyanov; Lina Mizrahi; Devorah Olam; Temima Schnitzer-Perlman; Eithan Galun; Daniel S Goldenberg
Journal:  Oncotarget       Date:  2017-05-30

2.  Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer.

Authors:  Martin Chevrier; Diwakar Bobbala; Alberto Villalobos-Hernandez; Md Gulam Musawwir Khan; Sheela Ramanathan; Caroline Saucier; Gerardo Ferbeyre; Sameh Geha; Subburaj Ilangumaran
Journal:  BMC Cancer       Date:  2017-02-24       Impact factor: 4.430

Review 3.  The Multifaceted p21 (Cip1/Waf1/CDKN1A) in Cell Differentiation, Migration and Cancer Therapy.

Authors:  Nina-Naomi Kreis; Frank Louwen; Juping Yuan
Journal:  Cancers (Basel)       Date:  2019-08-21       Impact factor: 6.639

Review 4.  p21 in Cancer Research.

Authors:  Bahar Shamloo; Sinem Usluer
Journal:  Cancers (Basel)       Date:  2019-08-14       Impact factor: 6.639

Review 5.  The Role of the Cyclin Dependent Kinase Inhibitor p21cip1/waf1 in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics.

Authors:  Samar Al Bitar; Hala Gali-Muhtasib
Journal:  Cancers (Basel)       Date:  2019-09-30       Impact factor: 6.639

Review 6.  Advances in the Current Understanding of How Low-Dose Radiation Affects the Cell Cycle.

Authors:  Md Gulam Musawwir Khan; Yi Wang
Journal:  Cells       Date:  2022-01-21       Impact factor: 6.600

7.  Correlation of Occupational Exposure to Carcinogenic Polycyclic Aromatic Hydrocarbons (cPAHs) and Blood Levels of p53 and p21 Proteins.

Authors:  Saleh A K Saleh; Heba M Adly; Imad A Aljahdali; Abdullah A Khafagy
Journal:  Biomolecules       Date:  2022-02-05

8.  Cytoplasmic p21 Mediates 5-Fluorouracil Resistance by Inhibiting Pro-Apoptotic Chk2.

Authors:  Arnatchai Maiuthed; Chuanpit Ninsontia; Katharina Erlenbach-Wuensch; Benardina Ndreshkjana; Julienne K Muenzner; Aylin Caliskan; Ahmed P Husayn; Chatchai Chaotham; Arndt Hartmann; Adriana Vial Roehe; Vijayalakshmi Mahadevan; Pithi Chanvorachote; Regine Schneider-Stock
Journal:  Cancers (Basel)       Date:  2018-10-09       Impact factor: 6.639

Review 9.  The Role of Cell Cycle Regulators in Cell Survival-Dual Functions of Cyclin-Dependent Kinase 20 and p21Cip1/Waf1.

Authors:  Lo Lai; Ga Yoon Shin; Hongyu Qiu
Journal:  Int J Mol Sci       Date:  2020-11-12       Impact factor: 5.923
  9 in total

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