Literature DB >> 2734978

Antiproliferative effect of interferons on human prostate carcinoma cell lines.

G Sica1, L Fabbroni, L Castagnetta, M Cacciatore, M Pavone-Macaluso.   

Abstract

The effect of purified human fibroblast beta-interferon (B-IFN) and recombinant alpha-2b-interferon (A-IFN) on cell proliferation was investigated in two human prostate carcinoma cell lines, named PC-3 and DU-145. Both cell lines respond to the antiproliferative action of interferon, B-IFN being more effective than A-IFN. PC-3 is more sensitive than DU-145 cell line, showing 95% inhibition of cell proliferation at the highest concentration of B-IFN. As interferons, besides reducing cell growth, are able to modify steroid receptor content in different hormone-sensitive human tumours, our results may be of some relevance as these drugs might be used to regulate both cell proliferation and hormone-sensitivity in prostate cancer.

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Year:  1989        PMID： 2734978     DOI： 10.1007/bf00262031

Source DB:  PubMed          Journal:  Urol Res        ISSN： 0300-5623


  16 in total

1.  Inhibition of DNA synthesis and alteration of cyclic adenosine 3',5'-monophosphate levels in RSa cells by human leukocyte interferon.

Authors:  A Fuse; T Kuwata
Journal:  J Natl Cancer Inst       Date:  1978-06       Impact factor: 13.506

2.  Effect of natural beta-interferon on cell proliferation and steroid receptor level in human breast cancer cells.

Authors:  G Sica; V Natoli; C Stella; S Del Bianco
Journal:  Cancer       Date:  1987-11-15       Impact factor: 6.860

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Authors:  L M Pfeffer; J S Murphy; I Tamm
Journal:  Exp Cell Res       Date:  1979-06       Impact factor: 3.905

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Authors:  K R Stone; D D Mickey; H Wunderli; G H Mickey; D F Paulson
Journal:  Int J Cancer       Date:  1978-03-15       Impact factor: 7.396

5.  Comparative antiproliferative activity in vitro of natural interferons alpha and beta for diploid and transformed human cells.

Authors:  E C Borden; T F Hogan; J G Voelkel
Journal:  Cancer Res       Date:  1982-12       Impact factor: 12.701

6.  Effect of interferon on concentrations of cyclic nucleotides in cultured cells.

Authors:  M G Tovey; C Rochette-Egly; M Castagna
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

7.  Sensitivity of human ovarian carcinoma cells to interferon and other antitumor agents as assessed by an in vitro semi-solid agar technique.

Authors:  L B Epstein; J T Shen; J S Abele; C C Reese
Journal:  Ann N Y Acad Sci       Date:  1980       Impact factor: 5.691

8.  Preclinical and clinical studies of interferons and interferon inducers in breast cancer.

Authors:  E C Borden; F R Balkwill
Journal:  Cancer       Date:  1984-02-01       Impact factor: 6.860

9.  Effect of human leukocyte interferon on the growth of human osteosarcoma cells in tissue culture.

Authors:  H Strander; S Einhorn
Journal:  Int J Cancer       Date:  1977-04-15       Impact factor: 7.396

10.  In vitro effects of beta-interferon on steroid receptors and prostaglandin output in human endometrial adenocarcinoma.

Authors:  F De Cicco; G Sica; M T Benedetto; G Ciabattoni; F Rossiello; A Nicosia; G Lupi; F Iacopino; S Mancuso; S Dell'Acqua
Journal:  J Steroid Biochem       Date:  1988       Impact factor: 4.292
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  7 in total

1.  Androgen receptors and hormone sensitivity of a human prostatic cancer cell line (PC-3) are modulated by natural beta-interferon.

Authors:  G Sica; G Dell'Acqua; F Iacopino; A Fattorossi; P Marchetti; T H van der Kwast; M Pavone-Macaluso
Journal:  Urol Res       Date:  1994

2.  Antitumor activity of interferon-β1a in hormone refractory prostate cancer with neuroendocrine differentiation.

Authors:  A Dicitore; E S Grassi; M O Borghi; G Gelmini; M C Cantone; G Gaudenzi; L Persani; M Caraglia; G Vitale
Journal:  J Endocrinol Invest       Date:  2017-03-01       Impact factor: 4.256

3.  Biochemical and immunological responses of hairy cell leukemia patients to interferon beta.

Authors:  A M Liberati; M Horisberger; M Schippa; F Di Clemente; M Fizzotti; S Filippo; M G Proietti; S Arzano; P Berruto; L Palmisano
Journal:  Cancer Immunol Immunother       Date:  1991       Impact factor: 6.968

4.  Cancer gene therapy using mesenchymal stem cells expressing interferon-beta in a mouse prostate cancer lung metastasis model.

Authors:  C Ren; S Kumar; D Chanda; L Kallman; J Chen; J D Mountz; S Ponnazhagan
Journal:  Gene Ther       Date:  2008-07-03       Impact factor: 5.250

5.  Effect of tumor necrosis factor-alpha and interferon-gamma on the growth of human prostate cancer cell lines.

Authors:  Y Nakajima; A DelliPizzi; C Mallouh; N R Ferreri
Journal:  Urol Res       Date:  1995

6.  IL6 sensitizes prostate cancer to the antiproliferative effect of IFNα2 through IRF9.

Authors:  Holger H H Erb; Regina V Langlechner; Patrizia L Moser; Florian Handle; Tineke Casneuf; Karin Verstraeten; Bettina Schlick; Georg Schäfer; Brett Hall; Kate Sasser; Zoran Culig; Frédéric R Santer
Journal:  Endocr Relat Cancer       Date:  2013-08-23       Impact factor: 5.678

7.  Combined genetic and epigenetic interferences with interferon signaling expose prostate cancer cells to viral infection.

Authors:  Oded Danziger; Ben Shai; Yosef Sabo; Eran Bacharach; Marcelo Ehrlich
Journal:  Oncotarget       Date:  2016-08-09
  7 in total

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