Investigations of trace elements in metastases and primary carcinoma of the prostate.

The concentration of several trace elements (Cd, Zn, Mn, Cr, Pb, Se) as determined both in primary prostatic carcinoma and in metastases of the same patients in unseparated and in separated tissue. In the unseparated tissue a significantly higher amount of all elements studied was found in the primary tumour. Different results were obtained for the concentrations in separated epithelium and stroma as well as in the cellular fractions of metastases and of primary tumour.