Yan-Ze Jin1, Chang-Zhu Pei1, Lan-Ying Wen1. 1. Department of Obstetrics & Gynecology, Yanbian University Hospital, 1327 Juzi-Road, Yanji 133000, Jilin Province, China.
Abstract
AIM: To investigate the expression of FLNA and its potential prognostic significance in cervical cancer. PATIENTS & METHODS: Real-time PCR was performed to evaluate the expression levels of FLNA in 44 pairs of cervical cancer and matched normal adjacent tissues. Kaplan-Meier analysis and Cox proportional hazards model were used to examine the correlation between FLNA expression levels and overall survival in cervical cancer patients. RESULTS & CONCLUSION: FLNA was significantly upregulated in cervical cancer tissues. FLNA expression level was associated with lymph node metastasis, parametrial invasion and response to neoadjuvant chemotherapy and predicted poor survival in cervical cancer patients. FLNA may serve as a predictor of chemosensitivity and a prognostic biomarker of survival in cervical cancer.
AIM: To investigate the expression of FLNA and its potential prognostic significance in cervical cancer. PATIENTS & METHODS: Real-time PCR was performed to evaluate the expression levels of FLNA in 44 pairs of cervical cancer and matched normal adjacent tissues. Kaplan-Meier analysis and Cox proportional hazards model were used to examine the correlation between FLNA expression levels and overall survival in cervical cancerpatients. RESULTS & CONCLUSION:FLNA was significantly upregulated in cervical cancer tissues. FLNA expression level was associated with lymph node metastasis, parametrial invasion and response to neoadjuvant chemotherapy and predicted poor survival in cervical cancerpatients. FLNA may serve as a predictor of chemosensitivity and a prognostic biomarker of survival in cervical cancer.
Authors: Shahana Dilruba; Alessia Grondana; Anke C Schiedel; Naoto T Ueno; Chandra Bartholomeusz; Jindrich Cinatl; Katie-May McLaughlin; Mark N Wass; Martin Michaelis; Ganna V Kalayda Journal: Cells Date: 2020-02-24 Impact factor: 6.600